The Protective Role of miR-486 for Alopecia Areata

    April 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    David Broadley, Andrey A. Sharov, John P. Sundberg, Marta Bertolini, Nilofer P. Farjo, Andrei N. Mardaryev, Natalia V. Botchkareva
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    TLDR miR-486 may help prevent hair loss in alopecia areata.
    The study from 2018 found that miR-486 plays a protective role in alopecia areata (AA) by maintaining hair follicle immune privilege. In female C3H/HeJ mice with AA, miR-486 expression was significantly lower in alopecic skin compared to healthy skin. Enhancing miR-486 levels in these mice prevented early hair follicle transition to the catagen phase and reduced immune cell infiltration and MHCI expression. Conversely, inhibiting miR-486 resulted in delayed hair growth and increased immune cell presence. Similar effects were observed in human hair follicles treated ex vivo. These findings suggest that miR-486 could be a potential therapeutic target for AA.
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