The Protective Role of miR-486 for Alopecia Areata

    April 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    David Broadley, Andrey A. Sharov, John P. Sundberg, Marta Bertolini, Nilofer P. Farjo, Andrei N. Mardaryev, Natalia V. Botchkareva
    Image of study
    TLDR miR-486 may help prevent hair loss in alopecia areata.
    The study from 2018 found that miR-486 plays a protective role in alopecia areata (AA) by maintaining hair follicle immune privilege. In female C3H/HeJ mice with AA, miR-486 expression was significantly lower in alopecic skin compared to healthy skin. Enhancing miR-486 levels in these mice prevented early hair follicle transition to the catagen phase and reduced immune cell infiltration and MHCI expression. Conversely, inhibiting miR-486 resulted in delayed hair growth and increased immune cell presence. Similar effects were observed in human hair follicles treated ex vivo. These findings suggest that miR-486 could be a potential therapeutic target for AA.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 23 results

      community Getting dutasteride in germany

      in Finasteride/Dutasteride  18 upvotes 5 months ago
      You can get dutasteride in Germany through the Teleclinic app, which sends a prescription to a nearby pharmacy. It costs around 18-19 euros for the prescription and 47 euros for 90 pills of Avodart 0.5.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Megadosing Koshine826(Pyrilutamide), my Plan.

      in Treatment  1 upvotes 3 months ago
      The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

      community Help in Germany to get recommended medicine

      in Finasteride/Dutasteride  5 upvotes 4 months ago
      A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

    Related Research

    5 / 5 results