From Wound to Hair Follicle: Unraveling the Mechanisms and Molecular Networks in Wound-Induced Hair Follicle Neogenesis

September 2025 in “ Wound Repair and Regeneration ”

Mingwei Shang, Ziyuan Tang, Weining Huang, Zhongrong Liu

wound-induced hair follicle neogenesis WIHN hair follicle development skin injury signaling pathways therapeutic strategies hairless scar formation

TLDR Understanding how new hair follicles form after skin injury could help prevent scars.

The review article discusses wound-induced hair follicle neogenesis (WIHN), a process where new hair follicles form following skin injury, observed in certain mammals. While WIHN shares similarities with embryonic hair follicle development, it also has distinct differences. The article highlights that despite significant research efforts, many aspects of WIHN remain unclear. Understanding the factors and signaling pathways involved in WIHN could lead to new therapeutic strategies for preventing hairless scar formation in humans.

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