Recent Trends in Nanocarrier Formulations of Actives Beyond Minoxidil and 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Management: A Systematic Review

    Tanaya D. Khairnar, Gaurav S. Chavan, Meenaz M. Sayyed, Nayan A. Gujarathi, Abhijeet A. Aher, Yogeeta O. Agrawal, Tulshidas S. Patil
    TLDR Nanocarrier-based treatments show promise for better hair growth in androgenetic alopecia but need more research.
    This systematic review discusses the potential of nanocarrier-based formulations for treating androgenetic alopecia (AGA) beyond traditional treatments like minoxidil and 5-α reductase inhibitors. It highlights the benefits of using nanotechnology for targeted drug delivery, including improved drug stability, skin penetration, and effectiveness in increasing hair follicle size and hair count. The review covers various drugs such as spironolactone, flutamide, and melatonin, showing promising results in enhancing hair growth. However, it notes that clinical studies on these formulations are limited in sample size and calls for more extensive research with diverse patient groups to validate these findings.
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