Male Androgenetic Alopecia

January 2023 in “ Springer eBooks ”

Dorothée Nashan, Eberhard Nieschlag

androgenetic alopecia hair loss pathophysiology hair cycles genetics sex hormones signal cascades male pattern baldness

TLDR New understanding of hair loss could lead to better treatments.

Androgenetic alopecia, a form of hair loss often associated with aging, can lead to psychosocial stigmatization. The document emphasizes the importance of discussing treatment options with patients after diagnosis, taking into account their preferences. It also highlights that recent advances in understanding the pathophysiology of hair cycles, genetics, sex hormones, and signal cascades could pave the way for new therapeutic developments for this condition.

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research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies

15 citations , July 2020 in “Experimental Dermatology”

Hormones and genes affect hair growth and male baldness.

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research Quality of Life Assessment in Patients with Androgenetic Alopecia

30 citations , July 2019 in “International Journal of Trichology”

research Correlation of Trichoscopic Findings in Androgenetic Alopecia and the Disease Severity

12 citations , May 2019 in “International Journal of Trichology”

research Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride

13 citations , March 2019 in “Dermatologic Therapy”

Finasteride effectively stops hair loss in most patients, but concerns about rare sexual side effects exist.

research The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

38 citations , February 2019 in “Clinical Interventions in Aging”

Dutasteride more effectively treats hair loss than finasteride, but may increase risk of altered libido.

research Evaluation of Long-Term Efficacy of Finasteride in Korean Men with Androgenetic Alopecia Using the Basic and Specific Classification System

11 citations , February 2019 in “Journal of Dermatology”

Finasteride effectively treats hair loss in Korean men for at least 5 years, with V type responding better.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , February 2019 in “Skin appendage disorders”

Some alternative treatments for hair loss might work, but more research is needed.

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

research Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version

36 citations , June 2018 in “Journal of Dermatology”

Use finasteride, dutasteride, and minoxidil for hair loss treatment.

research Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review

41 citations , February 2018 in “Lasers in Medical Science”

Low-Level Laser Therapy (LLLT) is a safe and effective treatment for common hair loss, but more research is needed to find the best power and wavelength for treatment.

research Efficacy of Topical Latanoprost Versus Minoxidil and Betamethasone Valerate on the Treatment of Alopecia Areata

15 citations , January 2018 in “Journal of Dermatological Treatment”

Latanoprost works better for hair growth, and combining it with betamethasone valerate is most effective.

research Meta-Analysis on Evidence of Platelet-Rich Plasma for Androgenetic Alopecia

29 citations , January 2018 in “International Journal of Trichology”

PRP treatment helps hair growth and density with 70.7% success, but more research needed.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations , January 2018 in “Journal of The European Academy of Dermatology and Venereology”

Use minoxidil for hair loss treatment; assess results after 6 months.

research Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders

16 citations , January 2018 in “Acta dermato-venereologica”

Prostanoids, like prostaglandins and thromboxane A2, can both enhance and inhibit hair growth, and understanding their effects could help treat hair disorders.

research New-Generation Therapies for the Treatment of Hair Loss in Men

15 citations , January 2018 in “Dermatologic Clinics”

New treatments for male hair loss show promise but need more research for safety and effectiveness.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia

13 citations , July 2017 in “Genomics”

Genomic approach finds new possible treatments for hair loss.

research Assessing Finasteride-Associated Sexual Dysfunction Using the FAERS Database

24 citations , June 2017 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride use linked to increased risk of sexual dysfunction, especially in younger people.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Bimatoprost for the Treatment of Eyelash, Eyebrow, and Scalp Alopecia

38 citations , March 2017 in “Expert Opinion on Investigational Drugs”

Bimatoprost is promising for treating some types of hair loss but needs more testing for androgenetic alopecia.

research Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

research Androgenetic Alopecia: An Update Of Treatment Options

110 citations , August 2016 in “Drugs”

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

research Guidelines on the Use of Finasteride in Androgenetic Alopecia

33 citations , March 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

Taking 1 mg of finasteride daily can increase hair count and improve hair appearance, but it may have side effects on sexual function and a potential risk of prostate cancer. It may not be effective for postmenopausal women unless taken in higher doses.

research Five-Year Efficacy of Finasteride in 801 Japanese Men with Androgenetic Alopecia

13 citations , July 2015 in “Journal of Dermatology”

Finasteride effectively promotes hair growth and reduces hair loss in men with androgenetic alopecia.

research Effect of Dutasteride 0.5 mg/day in Men with Androgenetic Alopecia Recalcitrant to Finasteride

36 citations , November 2014 in “International Journal of Dermatology”

Dutasteride helps hair growth in those unresponsive to finasteride, but may cause more sexual dysfunction.

research Evaluation and Diagnosis of the Hair Loss Patient

86 citations , September 2014 in “Journal of The American Academy of Dermatology”

To diagnose hair loss, use a systematic approach including history, exams, and tests.

research Scalp Dermatoscopic Findings in Androgenetic Alopecia and Their Relations with Disease Severity

30 citations , August 2014 in “Annals of Dermatology”

Scalp dermatoscopy helps diagnose and monitor hair loss severity.

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

66 citations , April 2014 in “Journal of Dermatological Treatment”

Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.

research Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

37 citations , April 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , March 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study

147 citations , January 2014 in “American Journal of Clinical Dermatology”

Laser device increases hair density, safe for treating hair loss in men and women.

research Androgen Actions on the Human Hair Follicle: Perspectives

115 citations , September 2012 in “Experimental Dermatology”

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations , May 2012 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

research Melatonin in the Topical Treatment of Androgenetic Alopecia

4 citations , August 2011 in “Aktuelle Dermatologie”

Topical melatonin is a safe treatment that may reduce hair loss in people with androgenetic alopecia.

research Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

170 citations , January 2010 in “Histopathology”

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

research Men With Kennedy Disease Have a Reduced Risk of Androgenetic Alopecia

41 citations , August 2007 in “British Journal of Dermatology”

Men with Kennedy disease have less chance of hair loss.

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations , January 2007 in “Human Genetics”

AR polyglycine repeat doesn't cause baldness.

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations , March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations , October 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

research New Findings in Hair Research: Influence of Prolactin, Retinoids, and Transforming Growth Factor-β on Hair Growth

3 citations , March 2005 in “Aktuelle Dermatologie”

Prolactin and TGF-β receptor blockers might help treat hair loss.

research Hair Shaft Abnormalities: Clues to Diagnosis and Treatment

44 citations , January 2005 in “Dermatology”

Hair problems can be caused by genetics or the environment, and treatment should focus on the cause and reducing hair damage.

research TrichoScan: A Novel Tool for the Analysis of Hair Growth In Vivo

70 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TrichoScan is a reliable method for measuring hair growth and is useful for assessing hair loss treatments.