Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle
February 2021
in “
Experimental Dermatology
”
cannabinoid receptor-1 CB1 MAPK pathway Akt pathway cytokeratin CK15 cytokeratin CK19 hair follicle bulge epithelial stem cells eSCs CB1 gene knockdown CB1 antagonist CB1 knockout mice endocannabinoid system CB1 receptor MAPK Akt CK15 CK19 hair follicle stem cells stem cells CB1 gene suppression CB1 blocker CB1 knockout
Studysummary This study found that activating CB1 receptor signaling in human hair follicles increased stem cell proliferation while reducing differentiated cell survival, suggesting CB1's role as a survival stimulus for epithelial stem cells.
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