Strategies to Utilize iPS Cells for Hair Follicle Regeneration and the Treatment of Hair Loss Disorders

    January 2021 in “ Elsevier eBooks ”
    Manabu Ohyama
    Studysummary This review discusses the potential of human induced pluripotent stem cells for regenerating hair follicles and developing cell-based therapies for hair loss, but it reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 50

    1. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    2. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    3. Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin Biochemical and Biophysical Research Communications · 2019
    4. Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration PubMed · 2019
    5. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee The Journal of Clinical Endocrinology and Metabolism · 2019
    6. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    7. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    8. Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version Journal of Dermatology · 2018
    9. Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss Journal of Dermatological Science · 2018
    10. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    11. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018
    12. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    13. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    14. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    15. Advances in Hair Restoration Dermatologic Clinics · 2017
    16. The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors Current Stem Cell Research & Therapy · 2017
    17. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    18. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    19. Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells Scientific Reports · 2017
    20. Identification of Factors Contributing to Phenotypic Divergence via Quantitative Image Analyses of Autosomal Recessive Woolly Hair/Hypotrichosis with Homozygous c.736T>A LIPH Mutation British journal of dermatology/British journal of dermatology, Supplement · 2016
    21. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    22. Restorative Effect of Hair Follicular Dermal Cells on Injured Human Hair Follicles in a Mouse Model Experimental Dermatology · 2015
    23. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    24. Effect of Dutasteride 0.5 mg/day in Men with Androgenetic Alopecia Recalcitrant to Finasteride International Journal of Dermatology · 2014
    25. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    26. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    27. Generation of iPS Cells from Human Hair Follicle Dermal Papilla Cells PubMed · 2014
    28. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    29. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    30. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    31. Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    32. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    33. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    34. Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells Journal of Investigative Dermatology · 2012
    35. Primary Cicatricial Alopecia: Recent Advances in Understanding and Management The Journal of Dermatology · 2011
    36. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    37. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    38. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    39. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009
    40. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    41. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    42. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    43. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    44. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    45. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    46. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    47. Telogen Effluvium: Causes, Diagnosis, and Treatment Clinical and Experimental Dermatology · 2002
    48. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    49. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    50. Hair Anatomy for the Clinician Journal of The American Academy of Dermatology · 1991

    Related research 6

    1. Hair Loss (Alopecia or Baldness) 2018
    2. A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth Experimental Dermatology · 2018
    3. Treatments of Hereditary Hair Loss (Alopecia) 2018
    4. Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells Journal of clinical & experimental dermatology research · 2014
    5. Fullerene Nanomaterials Potentiate Hair Growth Nanomedicine · 2009
    6. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001