Dual-Drug Nanostructured Lipid Carriers of Spironolactone and 2-Deoxy-D-Ribose for Targeted Follicular Delivery in Androgenetic Alopecia

    May 2026 in “ Drug Delivery and Translational Research ”
    Pritam Kayal, Manoj Kumar Mishra, N. Jawahar
    Studysummary Nanocarriers with spironolactone and 2-deoxy-D-ribose may improve hair loss treatment by targeting hair follicles directly.
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    Research cited in this study 29

    1. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    2. Nanocarrier-Based Approaches for Enhanced Management of Androgenetic Alopecia: Advancements and Future Prospects International Journal of Applied Pharmaceutics · 2025
    3. Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review Dermatology · 2024
    4. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024
    5. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    6. The Impact of Particle Size of Nanostructured Lipid Carriers on Follicular Drug Delivery: A Comprehensive Analysis of Mouse and Human Hair Follicle Penetration Bioimpacts · 2024
    7. Androgenetic Alopecia: An Update JAAD International · 2023
    8. Androgenetic Alopecia Updates: Pathophysiology, Diagnosis and Treatment International journal of dermatology, venereology and leprosy sciences · 2023
    9. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    10. Formulation Development and Investigations on Therapeutic Potential of Nanogel from Beta Vulgaris L. Extract in Testosterone-Induced Alopecia BioMed Research International · 2023
    11. Liquid Chromatography-Mass Spectrometry for Simultaneous Determination of Spironolactone and Canrenone in Plasma Samples Brazilian Journal of Pharmaceutical Sciences · 2023
    12. Skin Targeting of an Optimized Caffeine Nanostructured Lipid Carrier with Improved Efficiency Against Chemotherapy-Induced Alopecia International Journal of Applied Pharmaceutics · 2022
    13. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    14. Androgenetic Alopecia From A to Z Springer eBooks · 2022
    15. Topical Delivery of Fenugreek Seed Extract Loaded Solid Lipid Nanoparticles Based Hydrogels for Alopecia Journal of pharmaceutical research international · 2021
    16. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    17. RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells Annals of Dermatology · 2019
    18. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    19. Development and Optimization of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability Aaps Pharmscitech · 2016
    20. Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay BMC Complementary and Alternative Medicine · 2015
    21. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    22. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    23. Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies International Journal of Nanomedicine · 2014
    24. The Inhibitory Effect of Scutellaria Baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia Planta Medica · 2014
    25. Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carrier Gel for Effective Treatment of Alopecia Journal of The Saudi Pharmaceutical Society · 2013
    26. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    27. Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss PubMed · 2010
    28. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    29. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977