Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

    November 2014 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Shamma RN, Aburahma MH
    TLDR Nanostructured lipid carriers can effectively deliver spironolactone to hair follicles for treating hair loss.
    This study explored the use of nanostructured lipid carriers (NLCs) for delivering spironolactone (SL) directly to hair follicles to treat androgenic alopecia. The researchers aimed to enhance the drug's efficiency and safety by minimizing systemic side effects associated with oral administration. SL-loaded NLCs were created using an emulsion solvent diffusion and evaporation method, resulting in spherical particles with sizes ranging from 215.6 to 834.3 nm and an entrapment efficiency greater than 74%. The study found that SL existed in an amorphous form within the NLCs, and the drug release exhibited an initial burst followed by sustained release. Confocal laser scanning microscopy demonstrated the potential for these NLCs to deliver SL into hair follicles, indicating a promising approach for localized treatment of scalp disorders.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 501 results

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 7 months ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 7 months ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 9 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 1 year ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

    Similar Research

    5 / 1000+ results