Cell-free fat extract restores hair loss: a novel therapeutic strategy for androgenetic alopecia

    August 2023 in “Stem Cell Research & Therapy
    Yu Cai, Zhuoxuan Jia, Yichen Zhang, Bijun Kang, Chingyu Chen, Wei Liu, Wei Li, Wenjie Zhang
    TLDR A substance called Cell-free fat extract can effectively treat common hair loss by increasing hair growth and density.
    The study evaluated the effectiveness of Cell-free fat extract (CEFFE) in treating Androgenetic alopecia (AGA), a common hair loss disease. The research involved five groups of male C57BL/6 mice (n=12 in each group) treated with different concentrations of CEFFE for 18 days. The results showed that CEFFE-treated mice had an increased hair growth rate and hair coverage percentage. CEFFE also promoted the proliferation of dermal papilla cells (DPCs), modulated the cell cycle arrest, inhibited apoptosis caused by dihydrotestosterone (DHT), reduced the intracellular concentration of DHT in DPCs, and downregulated the expression of androgen receptor (AR). The study concluded that CEFFE is a novel and effective treatment for AGA, increasing hair follicle density and hair growth rate through the DHT/AR pathway regulation and regional angiogenesis ability.
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