Alopecia areata

    Lauren C. Strazzulla, Eddy Hsi Chun Wang, Lorena Avila, Kristen Lo Sicco, Nooshin Brinster, Angela M. Christiano, Jerry Shapiro
    Image of study
    TLDR Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
    The document from January 2018 provides an overview of Alopecia areata (AA), a common autoimmune hair loss condition affecting both sexes and all age groups, with a prevalence of 0.1% to 0.2%. It is characterized by immune-mediated destruction of hair follicles and inflammatory pathways upregulation. Trichoscopy can be used for diagnosis, showing specific features like exclamation point hairs. The severity of AA correlates with CD8+ T cell density, and genetic studies have implicated various immune-related genes. The C3H/HeJ mouse model has been instrumental in AA research. Factors such as atopy, other autoimmune conditions, stress, and diet may contribute to the risk of developing AA. A high soy oil diet may prevent AA by modulating inflammatory activity. The document also discusses the role of the JAK/STAT pathway in AA and suggests that stress hormones and diet can influence the condition's development.
    View this study on jaad.org →

    Cited in this study

    Related