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    PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology

    November 2019 in “ Experimental Dermatology ”
    Yuval Ramot, Marta Bertolini, M. Boboljova … Ralf Paus
    Studysummary This review synthesizes current research on PPAR-γ signaling in hair follicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 41

    1. Progressive Expression of PPARGC1α Is Associated with Hair Miniaturization in Androgenetic Alopecia Scientific Reports · 2019
    2. Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis British Journal of Dermatology · 2019
    3. Transepidermal UV Radiation of Scalp Skin Ex Vivo Induces Hair Follicle Damage That Is Alleviated by Topical Treatment with Caffeine International Journal of Cosmetic Science · 2019
    4. Wanted, Dead and Alive: Why a Multidisciplinary Approach Is Needed to Unlock Hair Treatment Potential Experimental Dermatology · 2019
    5. Anagen Hair Follicle Repair: Timely Regenerative Attempts from Plastic Extra-Bulge Epithelial Cells Experimental Dermatology · 2019
    6. An Update of the Pathogenesis of Frontal Fibrosing Alopecia: What Does the Current Evidence Tell Us? Australasian Journal of Dermatology · 2018
    7. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
    8. A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth Experimental Dermatology · 2018
    9. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    10. Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland Experimental Dermatology · 2018
    11. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    12. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    13. Adipose and Hair Function: An Apparent Connection Journal of Investigative Dermatology · 2018
    14. Peroxisome Proliferator-Activated Receptor-Gamma Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium Journal of Investigative Dermatology · 2018
    15. Eccrine Sweat Glands Associate With the Human Hair Follicle Within a Defined Compartment of Dermal White Adipose Tissue British Journal of Dermatology · 2018
    16. Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2 Scientific Reports · 2017
    17. Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris Journal of Investigative Dermatology · 2017
    18. PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017
    19. Absence of Vitamin D Receptor-Mediated PPARγ Suppression Causes Alopecia in VDR-Null Mice The FASEB Journal · 2016
    20. Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction Scientific Reports · 2016
    21. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    22. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    23. Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics? Archives of dermatological research · 2015
    24. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    25. The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology Experimental Dermatology · 2015
    26. The Use of Oral Pioglitazone in the Treatment of Lichen Planopilaris Journal of the American Academy of Dermatology · 2015
    27. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    28. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    29. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    30. Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    31. Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ Proceedings of the National Academy of Sciences of the United States of America · 2013
    32. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    33. Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients Journal of The American Academy of Dermatology · 2013
    34. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    35. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    36. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    37. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    38. Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist Archives of dermatology · 2009
    39. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    40. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    41. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000

    Related research 5

    1. Changes in the Hair Growth Cycle in Women with Non-Scarring Alopecia Vestnik dermatologii i venerologii · 2018
    2. Disorders of Hair DeckerMed Family Medicine · 2013
    3. Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression Australasian Journal of Dermatology · 2013
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006