Male Pattern Hair Loss: Can Developmental Origins Explain the Pattern?
May 2023
in “
Experimental Dermatology
”
male pattern hair loss MPHL miniaturization of hair follicles frontal scalp parietal regions androgens dihydrotestosterone DHT androgen receptors AR 5α-reductase frontal scalp fibroblasts neural crest cells mesoderm-derived induced pluripotent stem cells iPSCs direct reprogramming of fibroblasts male pattern baldness hair follicle shrinkage parietal scalp 5-alpha-reductase stem cells fibroblast reprogramming
Studysummary In this viewpoint, researchers discussed the possible role of the developmental origin of scalp dermis in influencing the specific pattern of hair follicle miniaturization seen in male pattern hair loss, noting that frontal follicles are more susceptible while occipital follicles remain largely terminal.
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