A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

    December 2022 in “ Bioactive Materials ”
    Zhaowenbin Zhang, Wenbo Li, Di Chang … Chen Yang
    Studysummary In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.
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    Research cited in this study 39

    1. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    2. Clinical Patterns of Hair Loss in Men Dermatologic Clinics · 2021
    3. Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia: A Review Biomedicines · 2021
    4. Platelet-Rich Plasma with Low Dose Oral Minoxidil (1.25 mg Versus 2.5 mg) Along with Trichoscopic Pre- and Post-Treatment Evaluation Journal of Cosmetic Dermatology · 2021
    5. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    6. Design of a Biofluid-Absorbing Bioactive Sandwich-Structured Zn–Si Bioceramic Composite Wound Dressing for Hair Follicle Regeneration and Skin Burn Wound Healing Bioactive Materials · 2020
    7. Microneedles Mediated Bioinspired Lipid Nanocarriers for Targeted Treatment of Alopecia Journal of Controlled Release · 2020
    8. Amelioration of Androgenetic Alopecia by Algal Oligosaccharides Prepared by Deep-Sea Bacterium Biodegradation Frontiers in Microbiology · 2020
    9. Microneedling: A Novel Therapeutic Approach for Androgenetic Alopecia, A Review of Literature Dermatologic Therapy · 2020
    10. Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia International Journal of Pharmaceutics · 2020
    11. Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin ACS Applied Materials & Interfaces · 2020
    12. Fibrosing Alopecia in a Pattern Distribution Journal of The American Academy of Dermatology · 2020
    13. Phospholipid-Polymer Hybrid Nanoparticle-Mediated Transfollicular Delivery of Quercetin: Prospective Implementation for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2019
    14. The Diagnosis of Androgenetic Alopecia in Children: Considerations of Pathophysiological Plausibility Australasian Journal of Dermatology · 2019
    15. Multifunctional Zinc-Doped Hollow Mesoporous Silica/Polycaprolactone Electrospun Membranes with Enhanced Hair Follicle Regeneration and Antibacterial Activity for Wound Healing Nanoscale · 2019
    16. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    17. Hair Follicle Development and Related Gene and Protein Expression in Rex Rabbits During the First 8 Weeks of Life Asian-Australasian Journal of Animal Sciences · 2018
    18. Finasteride Nano-Transferosomal Gel Formula for Management of Androgenetic Alopecia: Ex Vivo Investigational Approach Drug Design Development and Therapy · 2018
    19. Androgenetic Alopecia: A Review Endocrine · 2017
    20. Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment Fitoterapia · 2016
    21. Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice International journal of pharmacology · 2015
    22. Platelet-Rich Fibrin Matrix for Androgenetic Alopecia Facial Plastic Surgery · 2014
    23. Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo Growth Hormone & IGF Research · 2014
    24. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    25. Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat PLoS ONE · 2013
    26. Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study Drug Design Development and Therapy · 2013
    27. Nutrition and Hair: The Role of Nutrients in Hair Health Dermatologic Clinics · 2012
    28. Hair-Loss Preventing Effect of Grateloupia Elliptica Biomolecules & Therapeutics · 2012
    29. Characteristics of Androgenetic Alopecia in Asian Populations Annals of Dermatology · 2012
    30. The Role of Inflammation and Immunity in the Pathogenesis of Androgenetic Alopecia PubMed · 2011
    31. The Human Tri-Peptide GHK and Tissue Remodeling Journal of biomaterials science. Polymer ed. · 2008
    32. Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells Journal of Dermatological Science · 2007
    33. The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro Archives of Pharmacal Research · 2007
    34. Female-Patterned Alopecia in Teenage Brothers with Unusual Histologic Features Journal of Cutaneous Pathology · 2006
    35. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    36. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    37. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    38. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    39. Local Injection of Hepatocyte Growth Factor/Scatter Factor Alters Cyclic Growth of Murine Hair Follicles Journal of Investigative Dermatology · 1998