Beyond Scarring: Immune-Epithelial Crosstalk in Wound-Induced Hair Follicle Neogenesis

    July 2026 in “ Frontiers in Immunology ”
    Ying-Ming Ma, Wei Shen, Xiao-Lei Xie … Hui Sun
    Studysummary This review explores the mechanisms of wound-induced hair follicle neogenesis in mice, discussing its potential to inform precision therapies for alopecia and scarless wound healing, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 36

    1. From Wound to Hair Follicle: Unraveling the Mechanisms and Molecular Networks in Wound-Induced Hair Follicle Neogenesis Wound Repair and Regeneration · 2025
    2. Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies Cells · 2025
    3. Molecular Signaling Pathways in Wound-Induced Hair-Follicle Neogenesis Cells · 2025
    4. Microneedle-Mediated Hypoxic Extracellular Vesicle-Encapsulated Selenium Nanoparticles Delivery to Treat Androgenetic Alopecia Journal of Controlled Release · 2025
    5. The Role of Multiomics in Revealing the Mechanism of Skin Repair and Regeneration Frontiers in Pharmacology · 2025
    6. Dermal T Cell Immunity and Key Regulatory Signaling Pathways: Implications in Immune-Mediated Alopecia and Hair Regeneration Genes & Diseases · 2025
    7. TLR9 Activation in Large Wound Induces Tissue Repair and Hair Follicle Regeneration via γδT Cells Cell Death and Disease · 2024
    8. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    9. Regulatory T Cells in Skin Regeneration and Wound Healing Military Medical Research/Military medical research · 2023
    10. Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration Nature Communications · 2023
    11. Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration Molecules and Cells · 2023
    12. What Do We Know About Hair Growth Induced by Wounding and Its Therapeutic Applications? Dermatologic Surgery · 2023
    13. Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging Nature Aging · 2023
    14. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    15. Wound-Induced Hair Neogenesis Model Journal of Investigative Dermatology · 2022
    16. Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration Cold Spring Harbor Perspectives in Biology · 2022
    17. Cell Population Dynamics in Wound-Induced Hair Follicle Neogenesis Model Life · 2022
    18. May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis Current Opinion in Genetics & Development · 2021
    19. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    20. Hair of the Mouse: A Skin Bacteria Cocktail Gets Follicles Back on Their Feet Cell Host & Microbe · 2021
    21. Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging Frontiers in Cell and Developmental Biology · 2020
    22. Bacteria Induce Skin Regeneration Journal of Investigative Dermatology · 2020
    23. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    24. Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Areata: A Randomized Double-Blinded Parallel-Group Study Dermatology and Therapy · 2020
    25. Skin - A Vast Organ with Immunological Function (Review) Experimental and Therapeutic Medicine · 2020
    26. Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding Seminars in Cell & Developmental Biology · 2019
    27. Choreographing Immunity in the Skin Epithelial Barrier Immunity · 2019
    28. Embryonic-Like Regenerative Phenomenon: Wound-Induced Hair Follicle Neogenesis Regenerative Medicine · 2018
    29. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    30. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    31. Efficacy of Fractional Lasers in Treating Alopecia: A Literature Review Lasers in Medical Science · 2017
    32. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    33. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    34. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    35. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    36. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007