Cell Population Dynamics in Wound-Induced Hair Follicle Neogenesis Model
July 2022
in “
Life
”
TLDR Non-immune dermal cells dominate, epidermal cells increase after day 9, and certain immune cells persist beyond inflammation in wound-induced hair follicle regeneration.
The study investigates cell population dynamics in wound-induced hair follicle neogenesis (WIHN) in mice, using flow cytometry to analyze changes in various cell types at different time points post-wounding. Key findings include the dominance of non-immune dermal cells, an increase in epidermal cells from day 9 post-wounding, and the persistence of monocytes and neutrophils beyond the inflammatory phase. Most T cells in wounds were CD8+ and expressed γδTCR. The study provides a timeline for further research on cell subpopulations in WIHN, potentially aiding in strategies to reduce scarring and enhance hair follicle regeneration.
