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    Glossary Vesicles

    Vesicles are small, membrane-bound sacs within cells that transport and store various substances, including proteins, lipids, and neurotransmitters. In the context of hair biology, vesicles play a crucial role in the secretion of signaling molecules and growth factors that influence hair follicle development and cycling. Their function is particularly relevant in understanding hair loss, as disruptions in vesicle transport can affect the delivery of essential nutrients and signals necessary for healthy hair growth. Key distinguishing characteristics of vesicles include their lipid bilayer structure and their ability to fuse with other membranes to release their contents.

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    1. Transcutol containing vesicles for topical delivery of minoxidil Journal of Drug Targeting · 2010 · 51 citations
    2. Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus 1997 · 38 citations
    3. Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications Advanced Pharmaceutical Bulletin · 2021 · 33 citations
    4. Vesicles: Potential nano carriers for the delivery of skin cosmetics Journal of Cosmetic and Laser Therapy · 2017 · 21 citations
    5. Invasomes: Vesicles for Enhanced Skin Delivery of Drugs Springer eBooks · 2016 · 6 citations
    6. In vitro skin permeation of hinokitiol loaded in vesicles composed of behenyltrimethylammonium chloride and stearic acid Drug development and industrial pharmacy · 2010 · 5 citations
    7. In vivo hair re-growth efficacies of minoxidil preparations: distearyldimethylammonium chloride vesicles, cellulose acetate phthalate microparticles, and poloxamer solution Journal of Drug Delivery Science and Technology · 2009 · 2 citations
    8. Encapsulation of Clitoria ternatea L. blue flower petal extract in lipid vesicles for enhancing hair growth-promoting activity Journal of Health Science and Medical Research · 2026
    9. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020 · 220 citations
    10. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice Scientific Reports · 2017 · 113 citations
    11. Extracellular Vesicles in Skin Wound Healing Pharmaceuticals · 2021 · 106 citations
    12. Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation Stem Cell Research & Therapy · 2020 · 90 citations
    13. Extracellular vesicles as human therapeutics: A scoping review of the literature Journal of Extracellular Vesicles · 2024 · 88 citations
    14. Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies Signal Transduction and Targeted Therapy · 2025 · 77 citations
    15. Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles Stem Cell Research & Therapy · 2020 · 60 citations
    16. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020 · 51 citations
    17. Targeted delivery of extracellular vesicles: the mechanisms, techniques and therapeutic applications Molecular Biomedicine · 2024 · 41 citations
    18. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019 · 38 citations
    19. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019 · 37 citations
    20. Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice Journal of Nanobiotechnology · 2022 · 29 citations
    21. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil:<i>in vitro</i>evaluation of drug permeation by infrared spectroscopy Pharmaceutical Development and Technology · 2012 · 26 citations
    22. Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration Biomaterials · 2024 · 25 citations
    23. Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing Stem cell research & therapy · 2022 · 22 citations
    24. Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production Journal of Extracellular Vesicles · 2025 · 21 citations
    25. miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020 · 18 citations
    26. Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials? International Journal of Molecular Sciences · 2025 · 16 citations
    27. Methods and Challenges in Purifying Drug‐Loaded Extracellular Vesicles Journal of Extracellular Vesicles · 2025 · 15 citations
    28. Extracellular Vesicles for Regenerative Medicine Applications Applied Sciences · 2022 · 14 citations
    29. Development and characterization of phyto-vesicles of β-sitosterol for the treatment of androgenetic alopecia Archives of Dermatological Research · 2011 · 14 citations
    30. Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics Frontiers in cell and developmental biology · 2022 · 13 citations