Extracellular Vesicles Released from Irradiated Neonatal Mouse Cheek Tissue Increased Cell Survival After Radiation

October 2020 in “ Journal of radiation research ”

Kentaro Ariyoshi, Yota Hiroyama, Naoya Fujiwara, Tomisato Miura, Kosuke Kasai, Akifumi Nakata, Yohei Fujishima, Valerie Swee Ting Goh, Mitsuaki A. Yoshida

exosome-like vesicles ELV hair follicle loss radiation exposure fibroblast cell lines neonatal mouse cheek skin exosomes hair loss radiation fibroblasts

TLDR Vesicles from irradiated mouse cheek skin help cells survive radiation.

The study investigated the protective effects of exosome-like vesicles (ELV) secreted from irradiated neonatal mouse cheek skin on hair follicle loss after high-dose radiation. Neonatal mice exposed to 7 Gy X-ray showed overall hair growth defects except on their cheeks, suggesting a protective substance was secreted. The researchers found that ELV from irradiated cheek skin increased cell survival in mouse fibroblast cell lines, indicating that these vesicles might help prevent hair follicle loss after radiation exposure.

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Extracellular Vesicles Released from Irradiated Neonatal Mouse Cheek Tissue Increased Cell Survival After Radiation

Research cited in this study

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

research Apoptosis in Growing Hair Follicles Following Gamma-Irradiation and Application for the Evaluation of Radioprotective Agents

research The Biology of Hair Follicles

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