In Vivo Hair Re-Growth Efficacies of Minoxidil Preparations: Distearyldimethylammonium Chloride Vesicles, Cellulose Acetate Phthalate Microparticles, and Poloxamer Solution

January 2009 in “ Journal of Drug Delivery Science and Technology ”

Jung-Hyun Kim

minoxidil distearyldimethylammonium chloride cellulose acetate phthalate poloxamer hair re-growth skin permeation microparticles vesicles Rogaine DSDMAC CAP

TLDR Minoxidil in distearyldimethylammonium chloride vesicles significantly promotes hair growth, while minoxidil in microparticles or poloxamer solutions doesn't.

In a 2008 study, three minoxidil (MXD) preparations were tested for their hair re-growth efficacy: distearyldimethylammonium chloride (DSDMAC) vesicles, cellulose acetate phthalate microparticles, and poloxamer solution. The study found that MXD encapsulated in DSDMAC vesicles significantly promoted hair growth due to their small size, flexibility, and positive surface charge, which allowed for increased skin permeation and retention. In contrast, MXD in microparticles or poloxamer solutions did not show significant hair growth promotion.

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