In Vivo Hair Re-Growth Efficacies of Minoxidil Preparations: Distearyldimethylammonium Chloride Vesicles, Cellulose Acetate Phthalate Microparticles, and Poloxamer Solution

    January 2009 in “ Journal of Drug Delivery Science and Technology ”
    Jung-Hyun Kim
    Image of study
    TLDR Minoxidil in distearyldimethylammonium chloride vesicles significantly promotes hair growth, while minoxidil in microparticles or poloxamer solutions doesn't.
    In a 2008 study, three minoxidil (MXD) preparations were tested for their hair re-growth efficacy: distearyldimethylammonium chloride (DSDMAC) vesicles, cellulose acetate phthalate microparticles, and poloxamer solution. The study found that MXD encapsulated in DSDMAC vesicles significantly promoted hair growth due to their small size, flexibility, and positive surface charge, which allowed for increased skin permeation and retention. In contrast, MXD in microparticles or poloxamer solutions did not show significant hair growth promotion.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Reql minoxidil vs fake minoxidil (right)

      in Minoxidil  209 upvotes 1 day ago
      Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.

      community Smoking minoxidil, the theory that changes everything.

      in Minoxidil  512 upvotes 2 days ago
      A user humorously suggested smoking minoxidil in a blunt as an alternative hair growth method, sparking a satirical discussion on unconventional and unsafe ways to use minoxidil. The conversation included various suggestions like oral pills, rectal administration, and other absurd methods, with some users warning against the dangers of such practices.

      community Why don't Minoxidil regenerated hairs become terminal on the head?

      in Minoxidil  87 upvotes 2 days ago
      Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.

      community Be careful with minoxidil, even if it's just foam.

      in Minoxidil  12 upvotes 3 days ago
      Minoxidil caused side effects like chest pain and tinnitus for the user, leading them to stop using it and consider switching to finasteride with microneedling. Other users shared similar experiences with minoxidil, while some reported no issues, highlighting varied individual reactions.

      community 8 months on oral minoxidil. No sign of regrowth.

      in Minoxidil  14 upvotes 6 days ago
      The user has been taking 2mg oral minoxidil and 1mg finasteride but has seen no hair regrowth after 8 months, leading to concerns about being a non-responder. They are considering increasing the minoxidil dosage or switching to dutasteride, while also using keto shampoo and microneedling, but remain skeptical about the effectiveness of minoxidil.

      community Lowering dose of Oral Minoxidil?

      in Minoxidil  97 upvotes 6 days ago
      The user plans to lower their oral minoxidil dose from 5 mg to 2.5 mg to reduce side effects like puffiness and hypertrichosis, while also using finasteride and accutane. They are considering caffeine serums for puffiness and discussing dietary changes or switching to topical minoxidil to address bloating.

    Similar Research

    5 / 1000+ results