In Vivo Hair Re-Growth Efficacies of Minoxidil Preparations: Distearyldimethylammonium Chloride Vesicles, Cellulose Acetate Phthalate Microparticles, and Poloxamer Solution

    January 2009 in “ Journal of Drug Delivery Science and Technology ”
    Jung-Hyun Kim
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    Studysummary This study found that cationic vesicles enhanced minoxidil skin retention and in vivo hair growth efficacy compared to other formulation types due to electrostatic interactions with the skin. Our plain-language summary of this paper — not a Tressless recommendation.
    In a 2008 study, three minoxidil (MXD) preparations were tested for their hair re-growth efficacy: distearyldimethylammonium chloride (DSDMAC) vesicles, cellulose acetate phthalate microparticles, and poloxamer solution. The study found that MXD encapsulated in DSDMAC vesicles significantly promoted hair growth due to their small size, flexibility, and positive surface charge, which allowed for increased skin permeation and retention. In contrast, MXD in microparticles or poloxamer solutions did not show significant hair growth promotion.
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