Effect of a Non-Ionic Surfactant on Skin Retention of Cationic Minoxidil Microparticles Suspended in an Anionic Surfactant Solution

November 2009 in “ Korean journal of chemical engineering ”

Jin‐Chul Kim

minoxidil non-ionic surfactant cationic minoxidil microparticles anionic surfactant sodium lauryl ether sulfate skin retention Brij 78 Rogaine SLES

TLDR Adding Brij 78 to minoxidil microparticles in a certain solution helps them stick to the skin better and prevents clumping.

The study from 2009 found that adding Brij 78, a non-ionic surfactant, to cationic minoxidil (MXD) microparticles suspended in a solution with an anionic surfactant, sodium lauryl ether sulfate (SLES), prevented the microparticles from aggregating and increased their retention on the skin by approximately two-fold. This suggests that Brij 78 can enhance the stability and skin adherence of cationic drug microparticles, which could improve the effectiveness of particulate drugs in rinse-off cosmetic products. The study did not specify the number of subjects involved.

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Research cited in this study

2 / 2 results

research Substantivity and After-Rinsing Hair Growth Promotion of Cationic Microparticles of Minoxidil

2 citations, April 2008 in “Journal of Dispersion Science and Technology”

Shampoos with more than 0.6% of cationic minoxidil particles can promote hair growth.

research Minoxidil-Containing Dosage Forms: Skin Retention and After-Rinsing Hair-Growth Promotion

24 citations, January 2003 in “Drug Delivery”

Minoxidil-containing vesicles improve hair growth.

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