research Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole
Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.
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research TRPV3 Ion Channel: From Gene to Pharmacology
The TRPV3 ion channel is important for skin and hair health and could be a target for treating skin conditions.
research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes
A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.
research Nociceptive and Non-Nociceptive Roles of TRPV3 and Its Druggability
TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
research Skin Applications of Cannabidiol: Sources, Effects, Delivery Systems, Marketed Formulations and Safety
CBD may improve skin and hair health, but its effective use and safety need more research.
research Updated Strategies for the Management, Pathogenesis, and Molecular Genetics of Different Forms of Ichthyosis Syndromes with Prominent Hair Abnormalities
Early diagnosis and tailored treatments are crucial for managing ichthyosis syndromes with hair abnormalities.
research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases
Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth
Activating TRPV3 stops human hair growth.
research TRPV3 as a Therapeutic Target for Itch
Blocking TRPV3 may help treat itch in dry skin conditions.
research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice
The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
research Immune Cells May Have a Role in Hair Loss Process Caused by TRPV3 Gain-of-Function Mutation
Immune cells might contribute to hair loss caused by a specific mutation.
research Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses
Activating TRPV3 reduces skin oil production and increases inflammation, potentially causing dry skin issues.
research Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders
Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.
research News in Brief
Scientists found key proteins and genes that affect skin and hair health, and identified potential new treatments for hair loss, skin disorders, and wound healing.
research The Itchy Scalp: Scratching for an Explanation
Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.
research Potential Medical Uses of Cannabigerol: A Brief Overview
CBG may help with various medical conditions but needs more human research to confirm safety and effectiveness.
research Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching
Different ligands change the shape of the TRPV3 ion channel in unique ways.
research Whole Genome Sequencing Analysis of Alpaca Suggests TRPV3 as a Candidate Gene for the Suri Phenotype
The TRPV3 gene variant may cause the long-haired suri alpaca coat.
research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)
The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.
research Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits
N6-methyladenosine affects hair follicle development differently in Rex and Hycole rabbits.
research Pili Torti: A Feature of Numerous Congenital and Acquired Conditions
Pili torti is a rare condition where hair is twisted and breaks easily, often linked to genetic disorders or other health issues.
research The Endocannabinoid System of the Skin: A Potential Approach for the Treatment of Skin Disorders
Targeting the skin's endocannabinoid system could help treat skin disorders.
research TRP Channels in Skin Biology and Pathophysiology
TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
research Sensitive Skin
Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.
research Hair Follicle Stem Cells Promote Epidermal Regeneration Under Expanded Condition
Hair follicle stem cells help skin heal and grow during stretching.
research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations
Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System
Cannabinoids may help treat various skin conditions.
research RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development
RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.
research Cannabinoids and Their Receptors in Skin Diseases
Cannabinoids might help treat skin problems but more research is needed to be sure.
research Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2
Certain genetic changes in the LSS gene cause a rare skin and hair condition.