Whole Genome Sequencing Analysis of Alpaca Suggests TRPV3 as a Candidate Gene for the Suri Phenotype

February 2024 in “ BMC genomics ”

Stefano Pallotti, Matteo Picciolini, Giovanni Deiana, Dario Pediconi, Marco Antonini, Valerio Napolioni, C. Renieri

TRPV3 premature termination codon hair growth hair cycling G > T substitution amino acids protein dysfunction

Studysummary This study identified a gene variant in the TRPV3 gene that may explain the suri alpaca phenotype, characterized by longer and less crimped fleece, suggesting this variant's involvement in the development of these hair characteristics compared to the huacaya phenotype.

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research TRPV3 Ion Channel: From Gene to Pharmacology

2 citations , May 2023 in “International Journal of Molecular Sciences”

This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

11 citations , March 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that hair loss in an Olmsted syndrome mouse model with a Trpv3 mutation was linked to premature keratinocyte maturation, affecting hair follicle structure and function.

research Using WGCNA to Identify Hub Genes of Skin Hair Follicle Development in Fetal Stage of Inner Mongolia Cashmere Goat

16 citations , December 2020 in “PloS one”

In this study, WNT10A was identified as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

This study found that transcriptome profiling of cashmere goat skin revealed key genes and pathways involved in hair follicle initiation, differentiation, and maturation, which are critical for improving fleece production.

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

105 citations , May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that activation of the TRPV3 ion channel inhibits human hair growth by affecting hair follicles and outer root sheath keratinocytes.

research Hair Follicle Characteristics and Fiber Production in South American Camelids

27 citations , January 2010 in “Animal”

In these studies, researchers found that Peruvian camelids reach mature skin follicle development early, with specific cuticular characteristics useful for distinguishing fleece types, while Bolivian llamas have a mature follicle apparatus present at birth.

research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

59 citations , September 2007 in “Biochemical and Biophysical Research Communications”

This study found that a gain-of-function mutation in the TRPV3 channel leads to altered hair development in DS-Nh mice by affecting the anagen and telogen phases, highlighting TRPV3's role in hair growth regulation.