The Itchy Scalp: Scratching for an Explanation

October 2011 in “ Experimental dermatology ”

Ghada A. Bin Saif, Marna E. Ericson, Gil Yosipovitch

TLDR Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

The document reviewed the complex causes of scalp itchiness, linking it to dermatological conditions like psoriasis and atopic dermatitis. It discussed the roles of histamine, mast cells, neuropeptides, and proteinase-activated receptors in itch sensation. The involvement of TRP channels, particularly TRPV1 and TRPV3, in itch and inflammation was highlighted, along with the impact of neuropeptides like substance P and NGF on stress-induced hair growth inhibition. Cytokines such as interleukin-2 and interleukin-31 were also implicated in inducing itch and inflammation. The presence of Malassezia yeasts was associated with dandruff and seborrheic dermatitis. The review emphasized the need for further research to understand scalp pruritus mechanisms and develop effective treatments.

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