Updated Strategies for the Management, Pathogenesis, and Molecular Genetics of Different Forms of Ichthyosis Syndromes with Prominent Hair Abnormalities

The document reviewed various forms of ichthyosis syndromes with a focus on hair abnormalities, discussing their management, pathogenesis, and molecular genetics. It highlighted genetic mutations in genes like ST14, SPINK5, and MBTPS2, which affect processes such as profilaggrin processing and protease inhibition. Clinical features included follicular atrophoderma, hypotrichosis, and photophobia. Potential treatments discussed were acitretin and narrowband UVB phototherapy. The review emphasized the complexity of these syndromes, the importance of early diagnosis, and the need for tailored therapeutic strategies.