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    Did you mean Small Molecule Inhibitor?
    Glossary Small Molecule Inhibitor

    blocks specific proteins or enzymes within cells

    A Small Molecule Inhibitor (SMI) is a type of drug that can enter cells easily due to its low molecular weight and can interfere with specific proteins or enzymes to block their activity. These inhibitors are often used in treatments for various diseases, including cancer and autoimmune disorders, by targeting and disrupting specific pathways that contribute to disease progression.

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    Research 30 of 1000+

    1. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    2. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    3. Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration The FASEB Journal · 2016 · 94 citations
    4. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    5. The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine Journal of Cellular Physiology · 2017 · 89 citations
    6. High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth Research Square (Research Square) · 2024
    7. Recent Advances in Drug Development for Hair Loss International Journal of Molecular Sciences · 2025
    8. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    9. Inhibition of Wnt/β‐catenin pathway promotes regenerative repair of cutaneous and cartilage injury The FASEB Journal · 2015 · 41 citations
    10. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    11. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Signal Transduction and Targeted Therapy · 2022 · 318 citations
    12. Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair Experimental & Molecular Medicine · 2023 · 19 citations
    13. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    14. Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives Cells · 2020 · 24 citations
    15. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    16. ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth 2022
    17. Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth British Journal of Pharmacology · 2023 · 11 citations
    18. Stimulation of Hair Growth by Small Molecules that Activate Autophagy Cell reports · 2019 · 88 citations
    19. Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule Biochemical Pharmacology · 2025
    20. Colon Cancer Stem Cells: Promise of Targeted Therapy Gastroenterology · 2010 · 411 citations
    21. Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities Pharmacology & Therapeutics · 2018 · 140 citations
    22. Lgr5 Stem Cells and Potential Treatments for Hair Loss Theoretical and Natural Science · 2026
    23. Mechanisms of autophagy and their implications in dermatological disorders Frontiers in Immunology · 2024 · 6 citations
    24. Pathophysiological mechanisms of hair follicle regeneration and potential therapeutic strategies Stem Cell Research & Therapy · 2025
    25. Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia Journal of Dermatological Science · 2012 · 59 citations
    26. Small Molecule Treatments Improve Differentiation Potential of Human Amniotic Fluid Stem Cells Frontiers in Bioengineering and Biotechnology · 2021 · 11 citations
    27. Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling American Journal of Pathology · 2020 · 15 citations
    28. DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation Biochemical and Biophysical Research Communications · 2023 · 1 citations
    29. Transcutaneous electrical acustimulation promotes wound healing in mice by modulating signaling molecules and mitochondria function Archives of Dermatological Research · 2025 · 1 citations
    30. Gpr54 deletion accelerates hair cycle and hair regeneration EMBO Reports · 2024 · 1 citations