Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Tissue Regeneration

    August 2015 in “ MOJ proteomics & bioinformatics ”
    Hiroko Kato, Andy Lo, Shiuhyang Kuo, Song Nie, Cynthia L. Marcelo, David M. Lubman, Stephen E. Feinberg
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    TLDR ePUKs could be valuable for regenerative medicine due to their wound healing abilities.
    The study characterized a unique population of undifferentiated oral mucosa keratinocytes, termed "Epithelial-derived Pop-Up Keratinocytes (ePUKs)," using Gravity Assisted Cell Sorting (GACS) and LC/MS/MS analysis. These ePUKs exhibited increased expression of proteins such as DKK1, SERPINE1, follistatin, and tenascin-C, which are involved in cellular movement, hair follicle development, and stem cell niche maintenance. The use of ePUKs in fabricating tissue-engineered oral mucosa (EVPOME) showed enhanced protein abundance, suggesting that ePUKs could be a valuable cell source for regenerative medicine due to their wound healing promotion capabilities.
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