TLDR ePUKs could be valuable for regenerative medicine due to their wound healing abilities.
The study characterized a unique population of undifferentiated oral mucosa keratinocytes, termed "Epithelial-derived Pop-Up Keratinocytes (ePUKs)," using Gravity Assisted Cell Sorting (GACS) and LC/MS/MS analysis. These ePUKs exhibited increased expression of proteins such as DKK1, SERPINE1, follistatin, and tenascin-C, which are involved in cellular movement, hair follicle development, and stem cell niche maintenance. The use of ePUKs in fabricating tissue-engineered oral mucosa (EVPOME) showed enhanced protein abundance, suggesting that ePUKs could be a valuable cell source for regenerative medicine due to their wound healing promotion capabilities.
426 citations,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
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75 citations,
March 2014 in “Journal of Investigative Dermatology” Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
69 citations,
October 2013 in “Journal of Tissue Engineering and Regenerative Medicine” Current skin repair methods for severe burns are inadequate, but stem cells and new materials show promise for better healing.
28 citations,
December 2008 in “Laboratory investigation” Activin activation in skin cells speeds up wound healing without affecting scar quality.
81 citations,
January 2003 in “The FASEB Journal” Follistatin helps hair growth and cycling, while activin prevents it.
85 citations,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
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3 citations,
May 2023 in “Frontiers in immunology” Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.
508 citations,
February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
9 citations,
January 2017 in “Elsevier eBooks” Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
57 citations,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.
