Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells
July 2023
in “
Current Issues in Molecular Biology
”
TLDR Escin may help treat hair loss by boosting a specific cell growth pathway.
The study investigated the effects of escin, a natural compound, on the Wnt/β-catenin signaling pathway in human dermal papilla cells (hDPCs), which is associated with skin diseases like androgenetic alopecia. The research found that escin stimulated this pathway, leading to increased β-catenin and lymphoid enhancer-binding factor 1 (LEF1), and reduced the protein level of glycogen synthase kinase (GSK)-3β, a key regulator of this pathway. The study concluded that escin could potentially be used as a therapeutic solution for Wnt-related diseases such as androgenetic alopecia.
