Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

    July 2023 in “ Current Issues in Molecular Biology ”
    Jae Young Shin, Jaeyoon Kim, Yun Ho Choi, Sang-Hwa Lee, Nam Lyong Kang
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    Studysummary This study found that escin acts as a natural agonist of the Wnt/β-catenin signaling pathway in cultured human dermal papilla cells by promoting the degradation of GSK-3β, highlighting its potential therapeutic use for conditions like androgenetic alopecia and vitiligo. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the effects of escin, a natural compound, on the Wnt/β-catenin signaling pathway in human dermal papilla cells (hDPCs), which is associated with skin diseases like androgenetic alopecia. The research found that escin stimulated this pathway, leading to increased β-catenin and lymphoid enhancer-binding factor 1 (LEF1), and reduced the protein level of glycogen synthase kinase (GSK)-3β, a key regulator of this pathway. The study concluded that escin could potentially be used as a therapeutic solution for Wnt-related diseases such as androgenetic alopecia.
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