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This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.

This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

This study found that autophagy plays a role in sebaceous gland function and sebum composition control in mice lacking the Atg7 gene in keratinocytes.

This review discusses the pathogenesis of common sebaceous gland diseases and their molecular pathways, but it reports no new clinical findings.

This study found a significant reduction in the number and size of sebaceous glands in psoriatic skin lesions, indicating potential involvement in psoriatic alopecia.

This study observed that a topical liposome formulation of a 5‐α‐reductase inhibitor effectively reduced the size of treated sebaceous glands and induced apoptosis in a hamster model, suggesting potential benefits for acne treatment.

This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.

This study suggests that high proliferative activity and peripheral invasion are key indicators of malignancy in canine sebaceous gland tumours. It also reports a higher incidence of circumanal gland and testicular tumours, indicating a possible androgen-related pathway in tumour development.

In this study, mouse sebaceous glands were found to require nerves for growth during active hair cycles, suggesting a nerve-dependent sebaceous gland cycle coordinated with hair growth.

The authors concluded that Lrig1-positive stem cells are essential for sebaceous gland formation in mice, as their ablation led to temporary sebaceous gland disappearance without affecting hair growth.

In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.

This study found that testosterone and 5α-dihydrotestosterone affect human sebocytes differently depending on the skin region, with spironolactone inhibiting their proliferation and counteracting androgen effects in facial sebocytes.

This study found that MPZL3 plays a crucial role in controlling sebaceous gland size and sebocyte proliferation in mice and humans, implicating its potential involvement in skin disorders like acne and psoriasis.

This study indicates that MPZL3 negatively regulates sebaceous gland size in mice by controlling sebocyte proliferation, with implications for disorders like acne and psoriasis.

This review discusses the development, function, and complex roles of sebaceous glands in acne and suggests future acne treatments should target inflammation and lipid production; it reports no new clinical results.

This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.

This review discusses the roles of sebaceous gland activity, Malassezia yeast, and individual susceptibility in scalp flaking disorders, including dandruff and seborrheic dermatitis, but reports no new experiment results.

This study found that sebum in sebaceous glands is produced from cell populations derived from peripheral progenitor cells, similarly to hair growth, without direct involvement from other peripheral cells.

The researchers reported that Lrig1 overexpression was observed in 100% of sebaceous carcinoma cases, suggesting it may serve as a potential marker for poorly differentiated sebaceous carcinoma.

In this study, isotretinoin treatment significantly increased p53 expression in the skin of acne vulgaris patients, correlating with reduced acne severity and suggesting mechanisms for sebum suppression and side effects.

This study found that sebaceous-gland-derived glycerol significantly contributes to stratum corneum hydration in mice with sebaceous gland deficiencies.

This study reports that sebaceous glands can regenerate after injury through stem cell plasticity, with hair-follicle-derived stem cells replacing sebaceous gland progenitors and playing a crucial role in the regeneration process, which is dependent on FGFR2 signaling and aided by hair growth induction.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

The document concludes that scalp health is influenced by complex factors affecting sebaceous glands, including hormones, aging, and various substances.

This study found that applying α-mangostin-loaded nanoparticles significantly improved acne vulgaris in patients, with no notable skin irritation reported in human volunteers.

This study found that TGFβ signaling is essential for keeping sebocytes undifferentiated by reducing lipid-related gene expression, using a novel human sebocyte culture model.

This study found that K6a expression in mouse sebaceous gland ducts correlates with Hedgehog signaling, suggesting a role in duct fate.