Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumors with a Predominant Reserve Cell Population

    February 2015 in “ Journal of Comparative Pathology ”
    Silvia Sabattini, Patrizia Bassi, Giuliano Bettini
    Image of study
    TLDR High proliferative activity and peripheral invasion indicate malignancy in canine sebaceous gland tumors; the term 'epithelioma' should be updated for clarity.
    The study investigated 30 canine sebaceous gland tumors to determine histological criteria for malignancy, focusing on tumors with a predominant reserve cell population. It was found that both mitotic and Ki67 indexes, which measure tumor proliferative activity, were significantly higher in infiltrative tumors and correlated with each other. The study also observed a higher incidence of circumanal gland and testicular tumors in the dogs, suggesting a potential androgen-related pathway for tumorigenesis. Over an average follow-up of 754 days, three dogs were euthanized due to systemic metastases. The study concluded that high proliferative activity and peripheral invasion are key indicators of malignancy in these tumors, while the percentage of reserve cells and proliferative activity in mature sebocytes were not. The findings support the use of the Ki67 index as a prognostic marker and suggest that the term 'epithelioma' be replaced with more descriptive terms indicating tumor behavior.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 52 results

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  36 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community "DHT Itch" and onset Seborrheic Dermatitis

      in Research/Science  76 upvotes 1 year ago
      The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

      community Does finasteride/dutasteride reverse aging?

      in Chat  45 upvotes 1 month ago
      Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

    Similar Research

    5 / 1000+ results