Isotretinoin Treatment Upregulates the Expression of P53 in the Skin and Sebaceous Glands of Patients with Acne Vulgaris

    December 2022 in “ Archives of Dermatological Research ”
    Naglaa Agamia, Khalid Fawzi El Mulla, Naglaa Mohamed Alsayed, Rasha Mohamed Ghazala, Rania Elsayed Abdel El Maksoud, Iman Mohamed Abdelmeniem, Iman M. Talaat, Inass I Zaki, Rana Mohamed Sabah, Bodo C. Melnik
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    TLDR Acne treatment with isotretinoin increases the presence of p53, a protein, in skin and oil glands, which may help reduce acne severity.
    A study involving 40 participants (25 patients with acne vulgaris and 15 healthy controls) found that oral isotretinoin treatment significantly increased the expression of the transcription factor p53 in the skin and sebaceous glands. The patients were treated with isotretinoin for 6 weeks, and skin biopsies were taken before and after treatment. The results showed a significant increase in p53 expression in sebaceous glands and skin after treatment, with an inverse correlation to acne severity score and body mass index. The study concluded that isotretinoin induced the expression of p53, which controls multiple transcription factors involved in acne pathogenesis, and could explain the underlying transcriptomic changes causing sebum suppression and the adverse effects associated with isotretinoin therapy.
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