Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

The study investigated the roles of survivin and insulin-like growth factor-I (IGF-I) in the pathogenesis of acne vulgaris and postinflammatory acne scars. It found that both IGF-I and survivin were potentially involved in these conditions, with a significant positive correlation between their serum levels. This suggested that the IGF-I/PI3K/AKT pathway might downregulate FoxO transcription factors, leading to increased survivin expression, which could contribute to acne development and scarring. The study used ELISA kits to measure serum levels and Western blotting to assess tissue expressions, comparing patients with active acne and scars to healthy controls.