Scalp Sebaceous Physiology

January 2017 in “ Springer eBooks ”

Yahya Dowlati, Alireza Firooz, Hamed Zartab

TLDR The document concludes that scalp health is influenced by complex factors affecting sebaceous glands, including hormones, aging, and various substances.

The document "Scalp Sebaceous Physiology" examines the role of sebaceous glands in scalp health, detailing their structure, sebum production, and the factors that influence their function. It highlights that the scalp has a high density of these glands, which are affected by hormones and can be linked to conditions like scarring alopecia and androgenetic alopecia. The study also explores the effects of aging on gland function and how various substances, including Substance P, endocannabinoids, and capsaicin, can impact sebocyte activities like lipid synthesis, differentiation, and proliferation. The document underscores the complexity of sebaceous gland regulation by both internal and external factors.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Sebocytes’ Makeup: Novel Mechanisms and Concepts in the Physiology of the Human Sebaceous Glands

58 citations, March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv”

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations, February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations, February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Influence of Substance P on Cultured Sebocytes

46 citations, April 2008 in “Archives of Dermatological Research”

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

research Revisiting Dandruff: Role of Malassezia Yeasts and Treatment Implications

78 citations, September 2006 in “International Journal of Cosmetic Science”

Dandruff is mainly caused by a scalp reaction to yeast, can worsen hair loss, and antifungal treatments may help.

research Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development

147 citations, September 2006 in “Developmental Cell”

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations, January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

research Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

196 citations, May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sebocytes play a key role in controlling androgen levels in human skin.

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations, June 2000 in “The American journal of pathology”

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

research The Human Sebocyte Culture Model Provides New Insights Into Development and Management of Seborrhoea and Acne

198 citations, January 1998 in “Dermatology”

The human sebocyte culture model has improved understanding of oily skin and acne, and how they can be treated.

research Hair Anatomy for the Clinician

139 citations, July 1991 in “Journal of The American Academy of Dermatology”

Understanding hair follicle anatomy helps diagnose hair disorders.

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

51 citations, January 1989 in “Journal of Investigative Dermatology”

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

Related Community Posts Join

6 / 52 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 54 upvotes 3 days ago

community What Works to Restore Hairloss for Cis-Males? Not Much

in Treatment 18 upvotes 4 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community For Once and For All: Is It the DHT in the Scalp That Matters, Not the DHT in Your Bloodstream?

in Treatment 83 upvotes 2 months ago

DHT in the scalp, not the bloodstream, is crucial for hair loss. Treatments discussed include finasteride, minoxidil, dutasteride, and microneedling.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 36 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

Related Research

2 / 2 results

research Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland

30 citations, April 2018 in “Experimental Dermatology”

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

research Body to Scalp: Evolving Trends in Body Hair Transplantation

22 citations, January 2017 in “Indian Dermatology Online Journal”

Body hair transplants can treat baldness but differ from scalp hair and need more research on long-term results and side effects.