MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation

The study investigates the role of Myelin Protein Zero-like-3 (MPZL3) in the size and proliferation of sebaceous glands (SG) and sebocytes in mice. The research found that mice without MPZL3 showed an increase in SG size and sebocyte proliferation, suggesting that MPZL3 negatively regulates these factors. This was also observed in mice with a specific knockout of MPZL3 in the epithelia. MPZL3 mRNA and protein were found in human SGs, with mRNA expression localized to areas where sebocyte progenitors are found. The protein was also detected in the maturation and degenerative zones, possibly due to its longer half-life. The findings could have significant clinical implications, as disturbed SG homeostasis and function are seen in various skin conditions, including acne vulgaris, atopic dermatitis, cicatricial alopecia, psoriasis, seborrheic dermatitis, and benign or malignant SG tumors.