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GlossaryS100A2

protein involved in cell growth and differentiation

S100A2 is a protein that belongs to the S100 family, which is a group of proteins known for their role in regulating various cellular processes such as cell growth and differentiation. This protein is often studied in the context of cancer research because its expression levels can be altered in certain types of tumors, making it a potential biomarker for cancer diagnosis and prognosis.

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research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations, March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

86 citations, August 2011 in “Toxicological sciences”

TCDD speeds up skin barrier formation by increasing certain gene expressions.

research Bacteria Induce Skin Regeneration via IL-1β Signaling

53 citations, April 2021 in “Cell Host & Microbe”

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

research Identification of Differentially Expressed Genes in Actinic Keratosis Samples Treated with Ingenol Mebutate Gel

4 citations, May 2020 in “PLOS ONE”

Ingenol mebutate gel changes gene expression related to skin development and immune response in actinic keratosis.

research Blockade of S100A3 Activity Inhibits Murine Hair Growth

1 citations, January 2015 in “Genetics and Molecular Research”

Stopping S100A3 activity slows down hair growth in mice.

Natural Product Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

research Natural Product Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

May 2023 in “Research Square (Research Square)”

Shi-Bi-Man activates hair follicle stem cells and promotes hair growth by changing lactic acid metabolism and other cellular processes.

research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer

62 citations, February 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.

Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations, November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

research Protein Profiling of Forehead Epidermal Corneocytes Distinguishes Frontal Fibrosing From Androgenetic Alopecia

March 2023 in “PLOS ONE”

Protein profiling of forehead skin can help distinguish between frontal fibrosing alopecia and androgenetic alopecia.

research Significance of the S100A4 Protein in Psoriasis

45 citations, July 2009 in “Journal of Investigative Dermatology”

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

research Characterization of the Cysteine-Rich Calcium-Binding S100A3 Protein from Human Hair Cuticles

17 citations, December 2002 in “Biochemical and biophysical research communications”

Scientists found out how a specific protein in human hair cuticles behaves and is structured.

research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

4 citations, January 2017 in “Biological & pharmaceutical bulletin”

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

research Upregulation of SERPINB3/B4 and S100A7-9 in Hidradenitis Suppurativa/Acne Inversa

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain proteins are significantly increased in the skin of people with hidradenitis suppurativa.

Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations, June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs

12 citations, November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin 332 is essential for normal skin cell behavior and structure.

research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations, February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

research 3D-SeboSkin Model for Human Ex Vivo Studies of Hidradenitis Suppurativa/Acne Inversa

4 citations, June 2021 in “Dermatology”

Scientists created a 3D skin model to study a chronic skin disease and test treatments.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

3 citations, May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

research Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

2 citations, April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

research 3D-SeboSkin Model Application in Hidradenitis Suppurativa/Acne Inversa

September 2019 in “Journal of Investigative Dermatology”

The 3D-SeboSkin model effectively simulates Hidradenitis suppurativa and is useful for future research.

research Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin

62 citations, November 2009 in “Aging Cell”

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

research Isolation of Epithelial Stem Cells from Dermis by a Three-Dimensional Culture System

38 citations, January 2006 in “Journal of Cellular Biochemistry”

Researchers isolated a new type of stem cell from mouse skin that can renew itself and turn into multiple cell types.

Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

research Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

8 citations, March 2014 in “American Journal of Pathology”

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations, February 2022 in “Frontiers in cell and developmental biology”

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.