Abstracts

    May 2018 in “ Experimental Dermatology
    Lennart Emtestam, A. Al-Bayatti, Karin Popovic-Silwerfeldt, L. Weyler
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    TLDR Young HS patients often have other physical and mental health issues, and research on HS covers a wide range of topics including genetics, triggers, treatments, and the need for more data.
    The document contains abstracts from a conference that detail various studies and findings on Hidradenitis Suppurativa (HS) and related skin conditions. Key points include the high risk of somatic and mental disorders in young HS patients, with 34.0% of 153 cases having somatic comorbidity and 15.7% having a psychiatric diagnosis before age 18. Standardized photographic documentation of HS lesions, a paradoxical reaction to anti-TNF treatment, and the lack of evidence for HPV's role in HS carcinomatous transformation were discussed. Genetic predisposition studies suggest HS may be multigenic, and secondary prevention focusing on trigger identification and patient education was proposed. Familial HS cases show distinct clinico-epidemiological characteristics, and the Patient Benefit Index for HS was developed to assess treatment goals and needs. An epidemiological study called for more population-based data on HS in Germany. Further abstracts report on atypical HS cases, the influence of obesity and cigarette smoking on HS phenotype and severity, pro-atherogenic lipid profiles in HS patients, sex-specific differences in HS, dietary factors' role in HS, higher cannabis use among HS patients, and the poor inter-rater reliability of HS phenotypes by Canoui-Poitrine et al. Lastly, treatment-related findings include the limited usefulness of Canoui-Poitrine et al.'s HS phenotypes, the equal effectiveness of doxycycline and a clindamycin-rifampicin combination in treating HS in a small study, the potential of intralesional photodynamic therapy (I-PDT) as evidenced by a complete response in all 5 patients treated, and the questionable validity of traditional Indian medicine and homeopathy (TIMH) for HIV/AIDS due to methodological flaws in most studies. Only 4 studies were randomized controlled trials, and only 10 were published in MEDLINE-indexed journals.
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