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    Glossary Paracrine Factors

    signaling molecules affecting nearby cells within same tissue

    Paracrine factors are signaling molecules that are released by cells and affect nearby target cells within the same tissue. Unlike hormones that travel through the bloodstream to distant sites, paracrine factors act locally to regulate processes such as cell growth, differentiation, and immune responses. For example, in the context of hair growth, paracrine factors can influence the behavior of hair follicle cells, potentially impacting conditions like alopecia.

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    1. Comparative Study of Some Potential Paracrine Factors Produced by Normal and Androgenetic Alopecia Hair Follicles American journal of medical and biological research · 2015
    2. Narrow-band red LED light promotes mouse hair growth through paracrine growth factors from dermal papilla Journal of Dermatological Science · 2011 · 23 citations
    3. ‘Neurotrophology’ of the hair follicle: neurotrophins act as auto‐ and paracrine growth factors and immunomodulators Experimental dermatology · 2006
    4. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020 · 220 citations
    5. Local Injection of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) Alters Cyclic Growth of Murine Hair Follicles Journal of Investigative Dermatology · 1998 · 109 citations
    6. The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells Journal of Dermatological Science · 2001 · 47 citations
    7. Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells Experimental Dermatology · 2015 · 35 citations
    8. ACOS23O-002: The Use of Bone Marrow Mesenchymal Stem Cell Derived Cytokines and Growth Factors in The Management of Androgenetic Alopecia Journal of Asia Pacific Aesthetic Sciences · 2023
    9. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations
    10. Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶ Photochemistry and Photobiology · 2005 · 28 citations
    11. Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig. PubMed · 1992 · 11 citations
    12. Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism<sup>¶</sup> Photochemistry and Photobiology · 2005 · 3 citations
    13. Hair growth promoting effect of dermal papilla like tissues from canine adipose-derived mesenchymal stem cells through vascular endothelial growth factor Journal of Veterinary Medical Science · 2016 · 8 citations
    14. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages Nature Communications · 2016 · 115 citations
    15. Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model Frontiers in Cell and Developmental Biology · 2022 · 6 citations
    16. Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation International Journal of Molecular Sciences · 2019 · 166 citations
    17. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    18. Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine Journal of Tissue Engineering and Regenerative Medicine · 2019 · 88 citations
    19. The Hair Follicle: A Paradoxical Androgen Target Organ Hormone Research in Paediatrics · 2000 · 66 citations
    20. Emerging nonmetabolic functions of skin fat Nature Reviews Endocrinology · 2018 · 65 citations
    21. Keratinocytes regulate the function of melanocytes 2014 · 55 citations
    22. In vitro characterization of human hair follicle dermal sheath mesenchymal stromal cells and their potential in enhancing diabetic wound healing Cytotherapy · 2015 · 52 citations
    23. Defects in Androgen Biosynthesis Causing 46,XY Disorders of Sexual Development Seminars in reproductive medicine · 2012 · 46 citations
    24. Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery Pharmacology & Therapeutics · 2016 · 26 citations
    25. MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy Stem Cell Research & Therapy · 2021 · 25 citations
    26. Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis 2019 · 23 citations
    27. Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy World Journal of Stem Cells · 2024 · 16 citations
    28. Restoration of hair-inductive activity of cultured human follicular keratinocytes by co-culturing with dermal papilla cells Biochemical and Biophysical Research Communications · 2018 · 14 citations
    29. Effect of mesenchymal cells on human hair growth and death Korean Journal of Chemical Engineering · 2008 · 4 citations
    30. The involvement of androgens in human hair growth American journal of biomedical sciences · 2015 · 3 citations