The Roles of Hepatocyte Growth Factor Family Members in Androgen-Regulation of Human Hair Growth: A Comparison of the Expression of Hepatocyte Growth Factor Family Members, HGF and MSP, and Their Receptors, c-Met and RON, in Isolated Hair Follicles from Normal and Androgenetic Alopecia (Balding) Scalp
January 2010
TLDR Balding hair follicles have reduced growth factors and increased inhibitory factors, suggesting new treatment paths for hair loss.
This study investigated the role of hepatocyte growth factor (HGF) family members in androgen-regulated hair growth, particularly in androgenetic alopecia. By analyzing balding and non-balding scalp hair follicles using molecular biological methods, the researchers found that the dermal papilla and related cells expressed several HGF family genes, while matrix cells only produced the receptor RON, indicating autocrine roles for HGF and MSP and a paracrine route for MSP. The study revealed that in balding follicles, factors like IGF-I and SCF, which are typically increased during androgen stimulation, were reduced, while inhibitory factors like TGFß-1 were elevated. Additionally, HGF, MSP, and their receptors, c-Met and RON, were significantly reduced in balding follicles. These findings enhanced the understanding of androgen action in hair follicles and suggested potential pathways for developing better treatments for hair disorders.
