Studysummary This chapter reviews the clinical evidence of adding platelet-rich plasma to lipofilling for tissue regeneration, with suggestions of benefits in skin rejuvenation and wound healing, but lacks well-designed trials. Our plain-language summary of this paper — not a Tressless recommendation.
The chapter discusses the potential benefits and limitations of combining platelet-rich plasma (PRP) with lipofilling for tissue regeneration. Adipose tissue's regenerative capacity is attributed to the stromal vascular fraction (SVF), particularly adipose-derived stromal cells (ASCs), which aid in healing through angiogenesis, extracellular matrix remodeling, and immunomodulation. PRP enhances these effects by providing growth factors like VEGF and PDGF, potentially improving outcomes in skin rejuvenation, wound healing, dermal fibrosis, and androgenetic alopecia. However, despite promising case series, well-designed prospective clinical trials are still needed to confirm these benefits.
20 citations
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September 2019 in “Journal of Cosmetic Dermatology” This study found that combining stromal vascular fraction with PRP injections significantly improved hair density and reduced hair loss more effectively than PRP alone in patients with androgenetic alopecia.
40 citations
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March 2018 in “Aesthetic Surgery Journal” This study found that a single injection of platelet-rich stroma significantly increased hair density in men with androgenetic alopecia within 6 to 12 weeks, with no reported side effects.
88 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article reviews recent advancements in understanding and treating androgenetic alopecia, focusing on new genetic insights, stem cell roles, and diagnostic tools, without reporting new clinical results.
112 citations
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October 2005 in “Mayo Clinic Proceedings” This article reviews the clinical, psychological, and management aspects of androgenetic alopecia in men, stating that it can be effectively managed by generalist clinicians with pharmacotherapy and surgical advancements.
309 citations
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May 1993 in “Journal of The American Academy of Dermatology” This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.
