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Did you mean Myelin Protein Zero-Like 3?

GlossaryMyelin Protein Zero-Like 3

protein involved in hair follicle development and maintenance

Myelin Protein Zero-Like 3 (MPZL3) is a protein that plays a role in the development and maintenance of hair follicles. It is involved in cellular adhesion and signaling processes that are crucial for hair growth and regeneration. Mutations or dysregulation of MPZL3 can lead to hair disorders, including certain types of alopecia.

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research Deletion of Myelin Protein Zero-Like 3 Increases Sebaceous Gland Size and Sebocyte Proliferation but Reduces Skin Adipose Depots: Can MPZL3 Inhibition Promote Excessive Loss of Lipids via Sebum Hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

Deleting MPZL3 increases skin oil production and reduces body fat.

research Epithelially Derived, Mitochondrial MPZL3 Negatively Regulates Murine and Human Hair Follicle Cycling

April 2023 in “Journal of Investigative Dermatology”

A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.

research Hunting the Hair Cycle Clock: Evidence That Mitochondrially Localized MPZL3 Is a Key Element in Murine and Human Hair Follicles

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is important for controlling the hair growth cycle in mice and humans.

Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

research Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

14 citations, May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

research Hair Cycle Regulation by a Mitochondrially Localized Protein: Is MPZL3 a Central Component of the Elusive Hair Cycle Clock?

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein is important for controlling hair growth cycles.

research Epithelially Derived MPZL3 Negatively Regulates Murine and Human Sebaceous Gland Size and Sebocyte Proliferation

April 2023 in “Journal of Investigative Dermatology”

MPZL3 protein helps control the size of oil glands and the growth of oil-producing cells in both mice and humans.

research MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein helps keep sebaceous gland size and cell growth in check.

research Seborrhea-Like Dermatitis Phenotype in the Mpzl3 Knockout Mice

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 is crucial for seborrheic dermatitis development.

research Y27632 Promotes Proliferation via EGFR Signaling in a Newly Isolated and Characterized Human Primary Sebocyte Cell Line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

research Adenosine A2B Receptor: A Pathogenic Factor and a Therapeutic Target for Sensorineural Hearing Loss

8 citations, December 2020 in “The FASEB Journal”

Blocking adenosine A2B receptor may prevent or treat hearing loss.

research The Role of Immature and Mature Adipocytes in Hair Cycling

30 citations, December 2018 in “Trends in Endocrinology and Metabolism”

Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.

research Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives

February 2025 in “Stem Cell Research & Therapy”

Maintaining healthy mitochondria may help treat hair loss.

Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

January 2024 in “Aging”

New insights into cell communication in psoriasis suggest innovative drug treatments.

research CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance

11 citations, March 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of skin stem cells was found to help maintain hair follicle cells.

research Autophagy Dysfunction: The Kernel of Hair Loss?

May 2024 in “Clinical Cosmetic and Investigational Dermatology”

Manipulating cell cleanup processes could help treat hair loss.

research Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease

48 citations, June 2020 in “Current Rheumatology Reports”

Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.

research Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis

11 citations, February 2019 in “Stem cells international”

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.

research Transcriptomic Analysis to Identify Protective Dermal Papilla Signature in Occipital Scalp

April 2021 in “Journal of Investigative Dermatology”

The research found genes that may protect certain scalp cells from hair loss.

research Fibroblast Heterogeneity and Tertiary Lymphoid Tissues in the Kidney

9 citations, May 2021 in “Immunological Reviews”

Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.

research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

81 citations, April 2009 in “Journal of Investigative Dermatology”

Hair shedding is an active process that could be targeted to treat hair loss.

research Human Epidermal Neural Crest Stem Cells as a Source of Schwann Cells

44 citations, January 2015 in “Development”

Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.

Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

18 citations, March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease

26 citations, December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research Catalytic Antibodies in Normal and Systemic Lupus Erythematosus

25 citations, May 2017 in “InTech eBooks”

Catalytic antibodies are early indicators and active participants in the development of systemic lupus erythematosus.

research Therapeutic Potential of Hair Follicle-Derived Stem Cell Intranasal Transplantation in a Rat Model of Ischemic Stroke

8 citations, July 2022 in “BMC neuroscience”

Transplanted hair follicle stem cells improved brain function and reduced damage after a stroke in rats.

research CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties

41 citations, April 2019 in “PLOS genetics”

CD34+ and CD34- melanocyte stem cells have different regenerative abilities.

research New Developments in the Molecular Treatment of Ichthyosis: Review of the Literature

21 citations, July 2022 in “Orphanet journal of rare diseases”

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

research Differential Proteomics of Lesional vs. Non-Lesional Biopsies Revealed Non-Immune Mechanisms of Alopecia Areata

19 citations, January 2018 in “Scientific Reports”

Non-immune factors play a significant role in alopecia areata.

research Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

17 citations, November 2014 in “American Journal of Physiology-gastrointestinal and Liver Physiology”

Finasteride helps brain function in rats with liver-related brain issues.

research Mitochondrial Dysfunction in Diabetic Neuropathy May Be Involved in the Development of Neuropathic Pain via a Reduction in Neurosteroid Synthesis

4 citations, April 2017 in “F1000Research”

Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.