Catalytic Antibodies in Normal and Systemic Lupus Erythematosus

    May 2017 in “ InTech eBooks ”
    Georgy A. Nevinsky
    TLDR Catalytic antibodies are early indicators and active participants in the development of systemic lupus erythematosus.
    The study demonstrated that catalytic antibodies (abzymes) in systemic lupus erythematosus (SLE) exhibited diverse enzymatic activities, including DNase, RNase, and protease functions, which were not present in healthy individuals. These abzymes were cytotoxic and played a significant role in the pathogenesis of autoimmune diseases by hydrolyzing peptides, proteins, DNA, RNA, and oligosaccharides. The research highlighted the complexity and heterogeneity of abzymes, their metal ion dependencies, and their potential negative impact on disease progression. The findings suggested that abzymes could be critical in understanding autoimmune disease mechanisms and developing therapeutic strategies.
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