Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

    September 2020 in “ Frontiers in Immunology ”
    Gantsetseg Tumurkhuu, Shuang Chen, Erica N. Montano, Duygu Ercan Laguna, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, M Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Timothy R. Crother, Mariko Ishimori, Daniel J. Wallace, Caroline A. Jefferies, Moshe Arditi
    TLDR Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.
    The study concluded that oxidative DNA damage accelerated skin inflammation in a pristane-induced lupus model, with Ogg1-deficient (Ogg1−/−) mice showing increased inflammatory responses, hair loss, and skin pathology compared to wild-type mice. The findings highlighted the role of the DNA repair enzyme OGG1 in mitigating type I interferon responses and inflammation through the cGAS-STING pathway. Reduced OGG1 expression was also observed in SLE patients with skin involvement, suggesting that targeting oxidative DNA damage could be a potential therapeutic strategy for managing SLE-related skin inflammation.
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