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research Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

48 citations , September 2020 in “Frontiers in Immunology”

In this study, researchers found that loss of OGG1 in a mouse model of systemic lupus erythematosus increased IFN-driven immune responses and aggravated skin lesions, suggesting a protective role for OGG1 in SLE skin disease.

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

Increased IGF-1R expression is linked to thicker skin growth.

research Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice

11 citations , June 2012 in “Acta histochemica”

This study found that Gsdma3 mutations in mice led to thicker skin and longer hair infundibula, possibly by negatively regulating β-catenin expression in the epidermis.

research Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

409 citations , May 1991 in “Genes & Development”

This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.

research Structural and Pigmentary Characteristics of the Skin in Hairless Dog Breeds

October 2025 in “International Journal of Advanced Multidisciplinary Research and Studies”

This study found that hairless dog breeds have adapted to maintain normal body and core temperatures through structural changes like a thicker epidermis and the role of melanin in thermoregulation, with genetic mechanisms involving the FOXI3 gene governing hairlessness.

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community Important thing i discovered that makes ru58841 very effective

87 upvotes 7 months ago

RU58841 is more effective when mixed with isopropyl alcohol instead of minoxidil, as water in minoxidil degrades RU58841. Applying RU58841 separately from minoxidil, with an hour gap, enhances hair growth results.

community My microneedling journey (no min, fin, etc)

in Microneedling 210 upvotes 1 year ago

The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

community LLLT seems like it's at least a solid maintenance tool. Can also provide ok regrowth in AA and MPB. - Pubmed

17 upvotes 8 years ago

Low-Level Laser Therapy (LLLT) is seen as a safe and effective method for maintaining hair and promoting regrowth in androgenetic alopecia (AGA) and male pattern baldness (MPB), with devices like the HairMax LaserComb® and iRestore helmet being popular. Some users and professionals are skeptical about its long-term effectiveness and cost.

community Why is my dermatologist strictly against derma stamping/derma rolling?

in Microneedling 27 upvotes 1 year ago

Dermatologists often advise against at-home microneedling due to risks of scarring, infection, and improper technique. Professional guidance is recommended for safe and effective use, with some users reporting positive results when done correctly.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

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Learn

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learn Thymosin Beta 4

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Scalp Micropigmentation

Can Scalp Micropigmentation actually make hair look thicker, or is it just a cosmetic illusion? Scalp Micropigmentation creates the illusion of thicker hair by reducing scalp visibility.

learn Omega 3

Can a shampoo with omega-3s help thicken those early thinning spots? Shampoos with omega-3s may improve scalp health but won't thicken hair directly.

learn horsetail extract

How long should you use horsetail extract before noticing stronger or thicker hair? No published trial has tested horsetail extract for hair thinning, so no evidence-based timeline exists; the hair cycle means any supplement needs at least three months, and more realistically five to six, before a change could be visible at all.

learn Low Level Laser Therapy

How many sessions of laser therapy are usually needed before noticing thicker hair? Visible improvement in hair thickness typically appears after three to six months of treatment.

learn Stemoxydine

How long does it usually take to see thicker hair with stemoxydine products? The manufacturer's three-month studies, run in men only and published as a conference abstract, measured a density increase at about 12 weeks, so roughly three months is the earliest point supported by evidence. Nothing beyond three months has been tested in a controlled trial, and the change measured is extra visible hairs rather than regrowth of lost follicles.

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Maison EpidermisOrléans · FR

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