TLDR Non-immune factors play a significant role in alopecia areata.
The study on alopecia areata (AA) involving 10 patients used quantitative proteomics to compare lesional and non-lesional biopsies, revealing significant differences in protein expression. Specifically, 104 proteins were down-regulated, 4 were absent, 3 were up-regulated, and 11 were newly present in lesional biopsies. Key proteins such as α-tubulin, vimentin, HSP70, HSP90, annexin A2, and α-enolase showed decreased levels, confirmed by Western blotting. Network analysis indicated that down-regulated proteins were involved in tissue development, cell differentiation, and response to wounding, while up-regulated proteins were linked to metabolic processes and cellular transport. Notably, only 5 proteins were associated with immune regulation, suggesting non-immune mechanisms play a significant role in AA. This proteome dataset highlighted novel pathways potentially leading to new therapeutic targets for AA.
56 citations,
October 2016 in “Journal of dermatological science” New insights into the causes and treatments for the autoimmune hair loss condition Alopecia areata have been made.
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10 citations,
January 2016 in “PLOS ONE” Researchers found 44 proteins that change during different hair growth stages and may be important for hair follicle function.
65 citations,
December 2015 in “Experimental dermatology” Corticosteroid treatment reduces inflammation and alters hair keratins in alopecia areata.
62 citations,
January 2015 in “Journal of Dermatological Science” New genetic discoveries may lead to better treatments for alopecia areata.
162 citations,
October 2014 in “Autoimmunity reviews” Alopecia areata is caused by the immune system attacking hair follicles.
701 citations,
August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
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May 2011 in “Dermatologic therapy” New genetic discoveries in alopecia areata could lead to better treatments.
717 citations,
June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
48 citations,
May 1999 in “International Journal of Dermatology” Alopecia areata is an unpredictable autoimmune hair loss condition, treated based on severity, with half of patients regrowing hair within a year without treatment.
October 2023 in “Acta dermato-venereologica (Print)” People with severe hair loss have lower zinc levels in their blood.
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