Differential Proteomics of Lesional vs. Non-Lesional Biopsies Revealed Non-Immune Mechanisms of Alopecia Areata

    January 2018 in “ Scientific Reports ”
    Kanchalit Thanomkitti, Rattiyaporn Kanlaya, Kedsarin Fong‐ngern, Chompunoot Kapincharanon, Kanyarat Sueksakit, Prangwalai Chanchaem, Rattapon Thuangtong, Visith Thongboonkerd
    Image of study
    TLDR Non-immune factors play a significant role in alopecia areata.
    The study on alopecia areata (AA) involving 10 patients used quantitative proteomics to compare lesional and non-lesional biopsies, revealing significant differences in protein expression. Specifically, 104 proteins were down-regulated, 4 were absent, 3 were up-regulated, and 11 were newly present in lesional biopsies. Key proteins such as α-tubulin, vimentin, HSP70, HSP90, annexin A2, and α-enolase showed decreased levels, confirmed by Western blotting. Network analysis indicated that down-regulated proteins were involved in tissue development, cell differentiation, and response to wounding, while up-regulated proteins were linked to metabolic processes and cellular transport. Notably, only 5 proteins were associated with immune regulation, suggesting non-immune mechanisms play a significant role in AA. This proteome dataset highlighted novel pathways potentially leading to new therapeutic targets for AA.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 6 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 8 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

    Related Research

    1 / 1 results