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Glossary Myelin Protein Zero-Like 3

protein involved in hair follicle development and maintenance

Myelin Protein Zero-Like 3 (MPZL3) is a protein that plays a role in the development and maintenance of hair follicles. It is involved in cellular adhesion and signaling processes that are crucial for hair growth and regeneration. Mutations or dysregulation of MPZL3 can lead to hair disorders, including certain types of alopecia.

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Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

research Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis

14 citations , May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

This study found that mice lacking myelin protein zero-like 3 (Mpzl3) had reduced body weight and adiposity despite increased food intake, which was linked to higher energy expenditure and improved glycemic control.

research 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.

research 583 Hair cycle regulation by a mitochondrially localized protein: Is MPZL3 a central component of the elusive hair cycle clock?

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that MPZL3 plays a crucial role in regulating the hair cycle clock in mice, with its absence leading to accelerated hair follicle cycling and suggesting potential therapeutic pathways for alopecia treatment.

research 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo

1 citations , July 2024 in “Journal of Investigative Dermatology”

MPZL3 protein affects hair growth cycles and could help manage hair loss.

research 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling

April 2023 in “Journal of Investigative Dermatology”

This study suggests that MPZL3, a mitochondrially localized protein, may play an integral role in regulating hair follicle cycles, with potential therapeutic implications for hair growth disorders if findings translate to humans.

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