14 citations,
July 2013 in “American Journal of Physiology-endocrinology and Metabolism” Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.
November 2022 in “Journal of Investigative Dermatology” Deletion of Myelin Protein Zero-like 3 (MPZL3) in mice leads to increased sebaceous gland size and sebocyte proliferation, resulting in a greasy hair coat and enhanced sebum production. These Mpzl3 knockout mice also exhibit a 50% reduction in total adipose depots and resistance to high-fat diet-induced weight gain, despite increased food intake. The study found significant reductions in dermal white adipose tissue thickness and the number and size of dermal adipocytes in Mpzl3 -/- mice. These findings suggest that MPZL3 negatively regulates sebocyte proliferation and sebum production while promoting adipose tissue accumulation. The potential application of MPZL3 inhibitors in humans could offer a novel approach to obesity management by targeting sebaceous glands to reduce excessive lipid depots.
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” MPZL3 protein is important for controlling hair growth cycles.
April 2023 in “Journal of Investigative Dermatology” MPZL3 protein helps control the size of oil glands and the growth of oil-producing cells in both mice and humans.
April 2023 in “Journal of Investigative Dermatology” A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.