14 citations,
July 2013 in “American Journal of Physiology-endocrinology and Metabolism” Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.
November 2022 in “Journal of Investigative Dermatology” Deletion of Myelin Protein Zero-like 3 (MPZL3) in mice leads to increased sebaceous gland size and sebocyte proliferation, resulting in a greasy hair coat and enhanced sebum production. These Mpzl3 knockout mice also exhibit a 50% reduction in total adipose depots and resistance to high-fat diet-induced weight gain, despite increased food intake. The study found significant reductions in dermal white adipose tissue thickness and the number and size of dermal adipocytes in Mpzl3 -/- mice. These findings suggest that MPZL3 negatively regulates sebocyte proliferation and sebum production while promoting adipose tissue accumulation. The potential application of MPZL3 inhibitors in humans could offer a novel approach to obesity management by targeting sebaceous glands to reduce excessive lipid depots.
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” MPZL3 protein is important for controlling hair growth cycles.
April 2023 in “Journal of Investigative Dermatology” A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.
April 2023 in “Journal of Investigative Dermatology” MPZL3 protein helps control the size of oil glands and the growth of oil-producing cells in both mice and humans.