Seborrhea-Like Dermatitis Phenotype in the Mpzl3 Knockout Mice

The study investigated the inflammatory skin phenotype in Mpzl3 knockout (-/-) mice, which developed seborrhea-like dermatitis characterized by red skin, greasy hair, dandruff-like flaking, and excessive scratching. Histological analysis revealed acanthosis, hypergranulosis, hyperkeratosis, parakeratosis, and increased inflammatory cell infiltration. Immunofluorescent staining identified both innate and adaptive immune cells in the lesions, but inflammation also occurred in Mpzl3 and Rag2 double knockout mice, indicating that adaptive immunity was not necessary for inflammation onset. The findings suggested that MPZL3, regulated by ZNF750, played a crucial role in seborrheic dermatitis development, providing insights into the ZNF750-MPZL3 pathway's role in this condition.