April 2025 in “Dermatology Practical & Conceptual” In this study, researchers observed that individuals with premature graying of hair had significantly higher LC3 gene expression compared to controls, suggesting a potential link between autophagy and the development of this condition, with LC3 gene expression as a possible independent predictor.
October 2023 in “Dermatology practical & conceptual” This study observed that among 120 patients recovering from COVID-19, severe diffuse hair loss typically began less than two months post-infection, with the majority of patients experiencing a severe degree of hair loss and positive hair pull tests, often alongside vitamin D deficiency.
January 2026 in “Dermatology Practical & Conceptual” This systematic review found that exosome-based therapies significantly improve skin elasticity, reduce wrinkle depth, enhance hydration, and modulate pigmentation, with minimal adverse events reported across multiple studies. However, further clinical trials are necessary to confirm long-term efficacy and safety.
1 citations
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July 2025 in “Journal of Photochemistry and Photobiology B Biology” Photobiomodulation helps protect hair follicle cells from damage caused by DHT.
December 2025 in “Animals” In this study on fine-wool sheep, researchers found that overexpressing the TGFBR1 gene decreased proliferation of dermal papilla cells by influencing multiple signaling pathways, suggesting TGFBR1 as a negative regulator in hair follicle development.
May 2023 in “Research Square (Research Square)” This study found that botulinum toxin type A may reduce apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.
October 2024 in “Cosmetics” In this study, subthermal RF-CRET currents were found to alter key molecular mechanisms in dermal papilla cells, promoting proliferation and survival while enhancing markers associated with hair growth and maintenance, suggesting potential benefits for hair regeneration.
20 citations
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June 2020 in “Journal of Cosmetic Dermatology” This study found that hypoxia increases the proliferation of dermal papilla cells and highlighted the important role of lactate dehydrogenase in this process.
13 citations
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January 2016 in “Annals of Dermatology” This study found that acute stress in rats inhibits hair growth, likely through increased cortisol levels and activation of the substance P-mast cell pathway.
7 citations
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July 2024 in “Animals” In this study, the researchers observed that higher expression of the Sonic hedgehog gene in cashmere goats' hair follicle cycles is associated with increased cell proliferation and reduced apoptosis, suggesting its role in enhancing cashmere quality.
January 2024 in “Aesthetic Plastic Surgery” This study found that botulinum toxin type A inhibited apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.
August 2026 in “International Journal of Molecular Sciences” This study found that Atractylodes macrocephala Koidz. extract promotes anagen entry and hair regrowth by enhancing dermal papilla cell activity and supporting hair cycle progression in a mouse model.
17 citations
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July 2022 in “BMC Genomics” This study found that overexpression of the FA2H gene in cashmere goats' hair follicle cells may enhance hair proliferation and regulate genes affecting cashmere fineness.
13 citations
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June 2020 in “International Journal of Molecular Sciences” This study found that the humanin analogue HNG significantly promoted hair growth in vitro and in vivo by prolonging the anagen phase and inhibiting hair follicle cell apoptosis in mice.
3 citations
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December 2024 in “Journal of Animal Physiology and Animal Nutrition” In this study, researchers found that reducing FGF20 expression in dermal papilla cells of fine-wool sheep impedes the growth and differentiation of hair follicle stem cells, providing insights into wool trait improvement and regenerative medicine applications.
2 citations
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December 2024 in “Journal of Photochemistry and Photobiology B Biology” This study suggests that pulsed wave photobiomodulation could be a promising treatment for androgenetic alopecia by enhancing dermal papilla cell function through specific light parameters, particularly frequency.
1 citations
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November 2023 in “International Journal of Molecular Sciences” This study observed that SOX18 promotes the proliferation of dermal papilla cells in Hu sheep by activating the Wnt/β-Catenin signaling pathway, suggesting its key role in wool growth.
1 citations
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June 2023 in “Animals” In this study, researchers found that overexpression of CRABP2 enhanced the proliferation of dermal papilla cells in Hu sheep through activation of the Wnt/β-catenin pathway, even when the pathway was inhibited.
November 2025 in “Advanced Science” In this study, researchers found that a cold atmospheric plasma-activated hydrogel containing interleukin-2 significantly enhanced hair regeneration in a depilated mouse model, promoting larger hair follicles and faster hair growth phase transition, suggesting it as a potential treatment for hair loss.
December 2024 in “Regenerative Therapy” This study found that altering levels of SFRP1 in human dermal papilla cells affects cell function and regulates Wnt/β-catenin signaling or telomerase activity, suggesting that targeting SFRP1 could potentially offer a new approach to treat hair loss diseases.
October 2024 in “Current Issues in Molecular Biology” In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.
January 2024 in “Animals” This study suggests that the transcription factors SP1 and KROX20 regulate CUX1 gene's effect on the proliferation of ovine dermal papilla cells in vitro.
January 2023 in “Theranostics” This study reported that a curcumin-zinc microneedle patch improved hair regrowth and wound healing in animal models, suggesting potential as a versatile treatment for hair loss.
May 2025 in “Lasers in Medical Science” In this study, both erbium: YAG and erbium: glass lasers were found to be effective in treating androgenetic alopecia by improving hair density, growth rate, and thickness, particularly when combined with other therapies like minoxidil or platelet-rich plasma, though individual patient responses varied.
7 citations
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September 2003 in “Journal of Investigative Dermatology” In this study, researchers found that thrombin may influence cyclic hair growth through its receptor PAR-1, although it does not seem to stimulate dermal papilla cell proliferation physiologically.
March 2026 in “Frontiers in Veterinary Science” This study found that all-trans retinoic acid (ATRA) inhibits proliferation and promotes apoptosis in secondary hair follicle-derived dermal papilla cells from cashmere goats, likely via the TGF-β2/Smad2/3 signaling pathway.
This study found that FGF5 alternative spliceosomes inhibit dermal papilla cell proliferation and regulate hair follicle growth-related gene expression, impacting hair follicle development in rabbits.
September 2024 in “Genes” This study found that overexpressing CRABP1 in dermal papilla cells promotes their proliferation and influences key genes in the Wnt/β-catenin signaling pathway, which may offer insights into mechanisms controlling hair follicle development.
24 citations
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March 2024 in “Small Science” This review discusses the potential applications and advantages of encapsulating single cells for use in therapeutics and diagnostics, while also evaluating various methods for effectively creating and sorting single-cell units despite challenges in production and cost.
12 citations
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June 2022 in “International Journal of Molecular Sciences” In this study, copper was found to promote the proliferation of dermal papilla cells in Rex rabbits by maintaining the function of the cellular mitochondrial electron transport chain.