Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth

January 2016 in “ Annals of Dermatology ”

Hyoseung Shin, Soon‐Jin Choi, A‐Ri Cho, Dong Young Kim, Kyu Han Kim, Ohsang Kwon

acute stress cortisol substance P mast cells follicular dermal papilla cells hair growth hair follicle biology

TLDR Stress can slow hair growth by affecting certain cells and pathways.

The study suggested that acute stress inhibited hair growth through the release of cortisol, alongside the substance P-mast cell pathway. This indicated that stress could negatively impact hair growth by affecting follicular dermal papilla cells and mobilizing mast cells, highlighting the complex interactions between stress and hair follicle biology.

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Research cited in this study

12 / 12 results

research Enhancement of Human Hair Growth Using Ecklonia Cava Polyphenols

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Ecklonia cava polyphenols help increase human hair growth and reduce hair loss.

research A Role of Placental Growth Factor in Hair Growth

31 citations , February 2014 in “Journal of dermatological science”

Placental growth factor may help treat hair loss.

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

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research Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model

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Valproic acid may help hair grow and could be a safe treatment for hair loss.

research Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

research Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

23 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

research Promotive Effect of Minoxidil Combined with All-Trans Retinoic Acid (Tretinoin) on Human Hair Growth In Vitro

41 citations , January 2007 in “Journal of Korean Medical Science”

Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.

research Neuroimmunology of Stress: Skin Takes Center Stage

375 citations , July 2006 in “Journal of Investigative Dermatology”

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

research Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control

127 citations , December 2005 in “Experimental Dermatology”

Stress can stop hair growth in mice, and treatments can reverse this effect.

research Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition

76 citations , March 2005 in “Journal of Molecular Medicine”

Certain mice without specific receptors or mast cells don't lose hair from stress.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations , August 2004 in “Journal of Investigative Dermatology”

Hair loss causes stress and affects mental health; treatment and support needed.

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

125 citations , September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

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