The Role Of SFRP1 In Human Dermal Papilla Cell Growth And Its Potential Molecular Mechanisms As A Target In Regenerative Therapy

December 2024 in “ Regenerative Therapy ”

Chaofan Wang, Yimei Du, Changpei Lu, Lingbo Bi, Yunbu Ding, Weixin Fan

SFRP1 human dermal papilla cells Wnt/β-catenin signaling telomerase activity hair loss diseases

TLDR Inhibiting SFRP1 may help treat hair loss.

This study explores the role of Secreted Frizzled-Related Protein 1 (SFRP1) in human dermal papilla cells (DPCs) and its potential as a target for regenerative therapy in androgenetic alopecia (AGA). Elevated SFRP1 levels in AGA patients are linked to inhibited hair growth by negatively affecting β-catenin and TERT expression, crucial for hair follicle development. Inhibiting SFRP1 enhances cell viability, proliferation, and migration, suggesting that targeting SFRP1 could be a promising strategy for promoting hair growth in AGA patients.

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