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This study identified transcription elongation as a crucial regulatory factor in adipocyte cell fate, showing that the elongation factors Spt4 and Spt6 are essential for proper adipogenic differentiation by aiding RNA polymerase II progression through key adipogenic genes.

This study found that activating Wnt/beta-catenin signaling in hair follicles is sufficient to induce adipocyte generation in the dermis, affecting both hair follicle stem cell activation and adipocyte differentiation.

This study found that mice lacking REDD1 experienced an expansion of dermal white adipose tissue through both hypertrophy and hyperplasia, suggesting a potential therapeutic target for skin adipogenesis regulation.

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

This study found that in mice, knockout of Rac1 and Rac3 in keratinocytes led to reduced white adipose tissue and revealed Rac-dependent paracrine pathways affecting pre-adipocyte differentiation.

In this study, a wound-induced skin fibrosis model in mice revealed that TGFβ signaling plays a pivotal role in maintaining fibrogenic characteristics in dermal adipocyte progenitors, which could inform new therapeutic approaches for fibrotic skin conditions such as scleroderma.

This study found that Pdgfα signaling is crucial for maintaining dermal adipose tissue in mice by initiating dermal adipocyte stem cell proliferation, with implications for age-related skin defects.

In this study, deleting the transcriptional pause factor Nelfb in mouse preadipocyte lineages led to defective dermal fat formation and lethal outcomes, while interventions targeting Pparg could rescue adipocyte differentiation and promote dermal white adipose tissue formation, underscoring Nelfb's critical role in adipogenesis.

Human hair follicle cells can become fat and bone cells, useful for therapy.

This study found that topical rebamipide, originally a gastric ulcer medication, can activate hair follicle stem cells and promote hair regeneration by modulating dermal adipocyte metabolism, with potential targeting of the prostaglandin E receptor EP4.

This study found that inhibiting the enzyme PDE8A can promote adipocyte differentiation and enhance hair growth in an animal model of androgenetic alopecia, suggesting PDE8A as a potential therapeutic target for restoring dermal adipogenesis and hair cycling.

This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.

This study suggests that human skin contains distinct fibroblast subsets with unique expression profiles and functions, which can be isolated to investigate their role in skin pathogenesis.

This study found that hair follicle-derived dermal stem cells and bone marrow mesenchymal stem cells have similar growth, differentiation capabilities, and surface marker expressions, suggesting hair follicles could be accessible sources for mesenchymal stem cells.

This study explored the epigenetic mechanisms of dermal fibroblast progenitor differentiation and found that the repressive chromatin profile from H3K27me3 prevents these progenitors from reforming skin in allograft assays, despite their multipotent potential.

This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.

This study found that Dermal Fibroblast Progenitors have repressed chromatin profiles which hinder their ability to reform skin in allograft assays despite their differentiation potential.

This study found that in obese mice, local antimicrobial activity is reduced due to a loss of adipogenic stem cells and an increase in mature adipocytes, leading to higher susceptibility to skin infections.

The researchers in this study found that neonatal mouse skin fibroblasts show distinct chromatin landscapes directing differentiation into dermal papilla or adipocyte lineages, and such plasticity may inform strategies for enhancing regenerative capacities in adult skin.

New inhibitors may help treat hair loss by promoting fat cell growth in the skin.

In this study, researchers used yaks as a natural model to investigate hair growth mechanisms, overcoming previous limitations by establishing in vitro models of hair follicle-associated cells and optimizing methods for cell culture and differentiation.

In this study, researchers used a mouse model to identify an adipocyte-to-fibroblast conversion pathway that promotes mast-cell recruitment and dermal fibrosis in atopic dermatitis, suggesting a potential therapeutic approach to block this process and reduce inflammation and fibrosis.

This study suggests that targeting the increased expression of SIX1 in systemic sclerosis may be a viable strategy for addressing dermal fibrosis.

This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.

This review examines the literature on the molecular and cellular makeup of the hair follicle niche and how it influences stem cell behavior during hair regeneration, but does not provide new experimental results.

This study developed a new protocol to efficiently produce skin dermal stem cells from human induced pluripotent stem cells, which may aid in treating various skin disorders.

This study found that human dermal stem/progenitor cells demonstrated greater proliferation and differentiation potential than hair follicle dermal papilla cells, which showed increased expression of hair regeneration markers.

This practical guide introduces methods to study human dermal white adipose tissue but does not report new clinical results, emphasizing available techniques and staining protocols.

This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

This study found that mature adipocytes can dedifferentiate into fibroblast-like cells, driven by PDGF and TGFβ signaling, which may play a role in wound repair and fibrosis.